Canine E3 ubiquitin-protein ligase UHRF2 ELISA Kit | UHRF2 elisa kit

Canine E3 ubiquitin-protein ligase UHRF2 (UHRF2) ELISA Kit

Cat. Num. AAA2605220

• Gene Names: UHRF2; NIRF; URF2; RNF107; TDRD23
• Reactivity: Canine
• Synonyms: E3 ubiquitin-protein ligase UHRF2; Canine E3 ubiquitin-protein ligase UHRF2 (UHRF2) ELISA Kit; UHRF2 elisa kit

• Reactivity: Canine
• Sequence Length: 802

• Preparation and Storage: Store all reagents at 2-8 degree C.

NCBI and Uniprot Product Information

• NCBI GI #: 23312364
• NCBI GeneID: 115426
• NCBI Accession #: NP_690856.1
• NCBI GenBank Nucleotide #: NM_152896.2
• Molecular Weight: 56,077 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase UHRF2
• NCBI Official Synonym Full Names: ubiquitin like with PHD and ring finger domains 2
• NCBI Official Symbol: UHRF2
• NCBI Official Synonym Symbols: NIRF; URF2; RNF107; TDRD23
• NCBI Protein Information: E3 ubiquitin-protein ligase UHRF2
• UniProt Protein Name: E3 ubiquitin-protein ligase UHRF2
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: UHRF2
• UniProt Synonym Gene Names: NIRF; RNF107; Np95-like RING finger protein
• UniProt Entry Name: UHRF2_HUMAN

NCBI Description

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding. [provided by RefSeq, Feb 2012]

Uniprot Description

UHRF2: E3 ubiquitin-protein ligase that is an intermolecular hub protein in the cell cycle network. Through cooperative DNA and histone binding, may contribute to a tighter epigenetic control of gene expression in differentiated cells. Ubiquitinates cyclins, CCND1 and CCNE1, in an apparently phosphorylation-independent manner and induces G1 arrest. Also ubiquitinates PCNP leading to its degradation by the proteasome. Appears to contribute to tumorigenesis. Associated with various cancers. DNA copy number loss is found in multiple kinds of malignancies originating from the brain, breast, stomach, kidney, hematopoietic tissue and lung. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; EC 6.3.2.-; EC 6.3.2.19; Ligase; Ubiquitin conjugating system; Ubiquitin ligase

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: nuclear heterochromatin; nucleoplasm; nucleus

Molecular Function: histone binding; protein binding; ubiquitin-protein ligase activity

Biological Process: cell differentiation; cell proliferation; maintenance of DNA methylation; protein autoubiquitination; protein ubiquitination; regulation of cell cycle