Canine Acylglycerol kinase, mitochondrial (AGK) ELISA Kit | AGK elisa kit

Canine Acylglycerol kinase, mitochondrial (AGK) ELISA Kit

Cat. Num. AAA7222140

• Gene Names: AGK; MULK; CATC5; CTRCT38; MTDPS10
• Reactivity: Canine
• Synonyms: Acylglycerol kinase; mitochondrial (AGK); Canine Acylglycerol kinase; mitochondrial (AGK) ELISA Kit; AGK elisa kit

• Reactivity: Canine

• Samples: Serum, plasma, Cell Culture Supernatants, body fluid and tissue homogenate
• Preparation and Storage: Store all reagents at 2-8 degree C.

Product Categories/Family for AGK elisa kit

Epigenetics and Nuclear Signaling

NCBI and Uniprot Product Information

• NCBI GI #: 8922701
• NCBI GeneID: 55750
• NCBI Accession #: NP_060708.1
• NCBI GenBank Nucleotide #: NM_018238.3
• Molecular Weight: 7,634 Da
• NCBI Official Full Name: acylglycerol kinase, mitochondrial
• NCBI Official Synonym Full Names: acylglycerol kinase
• NCBI Official Symbol: AGK
• NCBI Official Synonym Symbols: MULK; CATC5; CTRCT38; MTDPS10
• NCBI Protein Information: acylglycerol kinase, mitochondrial; hAGK; hsMuLK; multi-substrate lipid kinase; multiple substrate lipid kinase
• UniProt Protein Name: Acylglycerol kinase, mitochondrial
• Protein Family: Acylglycerol kinase
• UniProt Gene Name: AGK
• UniProt Synonym Gene Names: MULK; hAGK; HsMuLK; MuLK; Multi-substrate lipid kinase
• UniProt Entry Name: AGK_HUMAN

NCBI Description

The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]

Uniprot Description

AGK: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively. Does not phosphorylate sphingosine. Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth. Defects in AGK are the cause of mitochondrial DNA depletion syndrome type 10 (MTDPS10). An autosomal recessive mitochondrial disorder characterized by congenital cataracts, hypertrophic cardiomyopathy, skeletal myopathy, exercise intolerance, and lactic acidosis. Mental development is normal, but affected individuals may die early from cardiomyopathy. Defects in AGK are the cause of cataract, congenital, autosomal recessive type 5 (CATC5). CATC5 consists of an opacification of the crystalline lens of the eye becoming evident at birth. It frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Motility/polarity/chemotaxis; Lipid Metabolism - glycerolipid; EC 2.7.1.94; EC 2.7.1.107; Kinase, lipid

Chromosomal Location of Human Ortholog: 7q34

Cellular Component: mitochondrion; intracellular membrane-bound organelle; mitochondrial membrane

Molecular Function: acylglycerol kinase activity; ceramide kinase activity; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity

Biological Process: protein kinase C activation; ceramide biosynthetic process; glycerolipid metabolic process; lipid phosphorylation

Disease: Cataract 38; Sengers Syndrome