Calcitonin receptor Recombinant Protein | CALCR recombinant protein

Calcitonin receptor Protein, Human, Recombinant (hFc Tag)

Cat. Num. AAA8121993

• Gene Names: CALCR; CRT; CTR; CT-R; CTR1
• Purity: >90% as determined by SDS-PAGE
• Synonyms: Calcitonin receptor; Calcitonin receptor Protein; Human; Recombinant (hFc Tag); Human CALCR/Calcitonin receptor Protein (Fc Tag); CRT Protein; CT-R Protein; CTR Protein; CTR1 Protein; calcitonin receptor; CALCR recombinant protein

• Host: HEK293 Cells
• Purity/Purification: >90% as determined by SDS-PAGE
• Form/Format: Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.
• Sequence: Ala25-Val154

• Species: Human
• Endotoxin: <1.0EU per ug protein as determined by the LAL method.
• Predicted N Terminal: Glu
• Tag: N-human IgG1-Fc
• Protein Construction: A DNA sequence encoding the human CALCR (NP_001158209.1)(Ala25-Val154) was expressed with the Fc region of human IgG1 at the N-terminus.
• Reconstitution: A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.
• Preparation and Storage: Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.; In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.; They are shipped out with blue ice.

SDS-Page

Product Categories/Family for CALCR recombinant protein

Calcium-binding Proteins and Related Molecules

NCBI and Uniprot Product Information

• NCBI GI #: 260064024
• NCBI GeneID: 799
• NCBI Accession #: NP_001158209.1
• NCBI GenBank Nucleotide #: NM_001164737.1
• UniProt Accession #: P30988; O14585; Q13941; Q5ZGL8; Q659U6; Q6DJU8; Q6T712; A4D1G6; F5H605
• Molecular Weight: 32,423 Da
• NCBI Official Full Name: calcitonin receptor isoform 1
• NCBI Official Synonym Full Names: calcitonin receptor
• NCBI Official Symbol: CALCR
• NCBI Official Synonym Symbols: CRT; CTR; CT-R; CTR1
• NCBI Protein Information: calcitonin receptor
• UniProt Protein Name: Calcitonin receptor
• Protein Family: Calcitonin receptor
• UniProt Gene Name: CALCR
• UniProt Synonym Gene Names: CT-R
• UniProt Entry Name: CALCR_HUMAN

NCBI Description

This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Uniprot Description

CALCR: This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; GPCR, family 2

Chromosomal Location of Human Ortholog: 7q21.3

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; calcitonin binding; receptor activity; protein transporter activity; calcitonin receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; protein transport; elevation of cytosolic calcium ion concentration; phospholipase C activation; receptor internalization; adenylate cyclase activation; response to glucocorticoid stimulus; positive regulation of cAMP biosynthetic process; positive regulation of adenylate cyclase activity; G-protein signaling, adenylate cyclase activating pathway

Disease: Osteoporosis