C4 Binding Protein Alpha Recombinant Protein | C4BPa recombinant protein

Recombinant C4 Binding Protein Alpha (C4BPa)

Cat. Num. AAA2033591

• Gene Names: C4bpa; C4BP
• Applications: SDS-Page, Western Blot, ELISA, Immunoprecipitation
• Purity: > 95%
• Synonyms: C4 Binding Protein Alpha; Recombinant C4 Binding Protein Alpha (C4BPa); C4BP-a; PRP; C4BP; Complement Component 4 Binding Protein; Alpha; Proline-rich protein; C4BPa recombinant protein

• Host: E Coli
• Purity/Purification: > 95%
• Form/Format: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Sequence: KCGP PPAIPNALPA SDVNRTDFES HTTLKYECLP GYGRGISRMM VYCKPSGEWE ISVSCAKKHC RNPGYLDNGY VNGETITFGS QIEFSCQEGF ILVGSSTSSC EVRGKGVAWS NPFPECVIVK CGPPPDISNG KHSGTEDFYP YNHGISYTCD PGFRLVGSPF IGCTVVNKTV PVWSSSPPTC EKIICSQPNI LHGVIVSGYK ATYTHRDSVR LACLNGTVLR GRHVIECQGNGNWSSLPTCE FDCDLP
• Sequence Length: 601

• Applicable Applications for C4BPa recombinant protein: SDS-PAGE, Western (WB), ELISA (EIA), Immunoprecipitation (IP).
• Predicted Molecular Mass: 30.8kDa
• Usage: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Endotoxin Level: <1.0EU per 1 ug (determined by the LAL method)
• Expression System: Prokaryotic expression
• Fragment: Lys57~Pro306
• Organism Species: Mouse
• Tag: two N-terminal Tags, His-tag and T7-tag
• Preparation and Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.; Stability Test: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.

SDS-Page

NCBI and Uniprot Product Information

• NCBI GI #: 77539456
• NCBI GeneID: 24235
• NCBI Accession #: NP_036648.2
• NCBI GenBank Nucleotide #: NM_012516.2
• Molecular Weight: 62,266 Da
• NCBI Official Full Name: C4b-binding protein alpha chain
• NCBI Official Synonym Full Names: complement component 4 binding protein, alpha
• NCBI Official Symbol: C4bpa
• NCBI Official Synonym Symbols: C4BP
• NCBI Protein Information: C4b-binding protein alpha chain
• UniProt Protein Name: C4b-binding protein alpha chain
• Protein Family: C4b-binding protein
• UniProt Gene Name: C4bpa
• UniProt Synonym Gene Names: C4bp
• UniProt Entry Name: C4BPA_RAT

NCBI Description

regulatory protein for the complement system of the innate immune response [RGD, Feb 2006]

Uniprot Description

Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. Alpha chain binds C4b. It interacts also with anticoagulant protein S and with serum amyloid P component.