Human Probable 4-hydroxy-2-oxoglutarate aldolase ELISA Kit | C10orf65 elisa kit
Human Probable 4-hydroxy-2-oxoglutarate aldolase, mitochondrial (C10orf65) ELISA Kit
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV
NCBI and Uniprot Product Information
NCBI Description
The authors of PMID:20797690 cloned this gene while searching for genes in a region of chromosome 10 linked to primary hyperoxalurea type III. They noted that even though the encoded protein has been described as a mitochondrial dihydrodipicolinate synthase-like enzyme, it shares little homology with E. coli dihydrodipicolinate synthase (Dhdps), particularly in the putative substrate-binding region. Moreover, neither lysine biosynthesis nor sialic acid metabolism, for which Dhdps is responsible, occurs in vertebrate mitochondria. They propose that this gene encodes mitochondrial 4-hydroxyl-2-oxoglutarate aldolase (EC 4.1.3.16), which catalyzes the final step in the metabolic pathway of hydroxyproline, releasing glyoxylate and pyruvate. This gene is predominantly expressed in the liver and kidney, and mutations in this gene are found in patients with primary hyperoxalurea type III. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Nov 2010]
Uniprot Description
DHDPSL: Catalyzes the final step in the metabolic pathway of hydroxyproline (Probable). Defects in HOGA1 are the cause of hyperoxaluria primary type 3 (HP3); also known as primary hyperoxaluria type III (PH3). HP3 is a disorder where the main clinical manifestation is calcium oxalate nephrolithiasis though chronic as well as terminal renal insufficiency has been described. It is characterized by an elevated urinary excretion of oxalate and L- glycerate. Belongs to the DHDPS family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: EC 4.1.3.16; Lyase; Mitochondrial
Chromosomal Location of Human Ortholog: 10q24.2
Cellular Component: mitochondrial matrix; mitochondrion
Molecular Function: 4-hydroxy-2-oxoglutarate aldolase activity; protein homodimerization activity
Biological Process: 4-hydroxyproline catabolic process; glyoxylate catabolic process; glyoxylate metabolic process; oxalate metabolic process; pyruvate biosynthetic process
Disease: Hyperoxaluria, Primary, Type Iii
Research Articles on C10orf65
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Product Notes
The Human C10orf65 hoga1 (Catalog #AAA280348) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA280348 ELISA Kit recognizes Human C10orf65. It is sometimes possible for the material contained within the vial of "Probable 4-hydroxy-2-oxoglutarate aldolase, ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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