C-type natriuretic peptide Recombinant Protein
Recombinant Ornithorhynchus anatinus C-type natriuretic peptide
NCBI and Uniprot Product Information
Uniprot Description
Function: Venom component with vasorelaxant activity. In vitro stimulates the production of cGMP in rat aortic smooth muscle cells and histamine release from rat peritoneal mast cells. Induces relaxation of isolated rat uterus. Induces local edema following subplantar injection into rat hind paw. Forms voltage-dependent cation channels which are weakly selective for potassium relative to sodium, and whose conductance decreases with increasing dehydration energy of the monovalent cation. The activity of the fast cation channels is calcium dependent and is characterized by short bursts of current separated by long periods of inactivation. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7Venom peptide 1 induces slow and continuous calcium influx in IMR-32 human neuroblastoma cells. Venom peptide 4 weakly induces calcium influx in IMR-32 human neuroblastoma cells while venom peptide 2 was not observed to induce calcium influx. Ref.2 Ref.3 Ref.4 Ref.5 Ref.6 Ref.7
Subcellular location: Secreted Ref.3 Ref.4 Ref.5.
Tissue specificity: Expressed by the venom gland. Ref.3 Ref.4 Ref.5
Post-translational modification: Stereoinversion of L-Leu-84 (in ovCNP-39a) to D-Leu-84 (in ovCNP-39b).
Sequence similarities: Belongs to the natriuretic peptide family.
Mass spectrometry: Molecular mass is 4207.9 Da from positions 83 - 121. Determined by MALDI. Ref.3Molecular mass is 4208.3 Da from positions 83 - 121. Determined by MALDI. Ref.3Molecular mass is 4212 Da from positions 83 - 121. Determined by MALDI. Ref.4
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Product Notes
The C-type natriuretic peptide (Catalog #AAA1154168) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 45-63aa; Cytoplasmic domain. The amino acid sequence is listed below: ANGGGK KGDKEPKGDR PRL. It is sometimes possible for the material contained within the vial of "C-type natriuretic peptide, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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