Human budding uninhibited by benzimidazoles 3 homolog (yeast) ELISA Kit | BUB3 elisa kit
Human Mitotic checkpoint protein BUB3, BUB3 ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a protein involved in spindle checkpoint function. The encoded protein contains four WD repeat domains and has sequence similarity with the yeast BUB3 protein. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Uniprot Description
BUB3: Has a dual function in spindle-assembly checkpoint signaling and in promoting the establishment of correct kinetochore-microtubule (K-MT) attachments. Promotes the formation of stable end-on bipolar attachments. Necessary for kinetochore localization of BUB1. Regulates chromosome segregation during oocyte meiosis. The BUB1/BUB3 complex plays a role in the inhibition of anaphase-promoting complex or cyclosome (APC/C) when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Interacts with BUB1 and BUBR1. The BUB1/BUB3 complex interacts with MAD1L1. Belongs to the WD repeat BUB3 family. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 10q26
Cellular Component: kinetochore; nucleoplasm; cytosol
Molecular Function: protein binding
Biological Process: negative regulation of ubiquitin-protein ligase activity during mitotic cell cycle; meiotic cell cycle; mitotic sister chromatid segregation; regulation of ubiquitin-protein ligase activity during mitotic cell cycle; anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process; cell division; mitotic cell cycle spindle assembly checkpoint; mitotic cell cycle; attachment of spindle microtubules to kinetochore
Research Articles on BUB3
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Product Notes
The Human BUB3 bub3 (Catalog #AAA9327893) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA9327893 ELISA Kit recognizes Human BUB3. It is sometimes possible for the material contained within the vial of "budding uninhibited by benzimidazoles 3 homolog (yeast), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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