HVEM-Fc active protein
HVEM-Fc protein
Applications
User optimized
Purity
>= 98% by SDS-PAGE and HPLC
Synonyms
HVEM-Fc; HVEM-Fc protein; HVEM protein; TR2 protein; TNFSFR14 protein; ATAR protein; HVEM-Fc active protein
Host
(BTI-Tn-5B1-4) Hi-5 Insect Cells
Purity/Purification
>= 98% by SDS-PAGE and HPLC
Form/Format
Lyophilized powder from 1x PBS, pH 7.2. Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex.
Concentration
100ug Lyophilized (varies by lot)
Sequence
Region of HVEM protein corresponding to amino acids LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK. Conjugated to Fc.
Applicable Applications for HVEM-Fc active protein
User optimized
Species
Human
Biohazard
Use appropiate laboratory precautions when handling this material.
Grade
Recombinant
Bioactivity
Determined by its ability to neutralize 0.25 ng/ml of hTNFbeta induced cytotoxicity on Mouse L929 cells. The expected ED50 for this effect is 1.3-1.9 ug/ml of HVEM-Fc.
Contaminants
Endotoxin: <0.1ng/ug(<1EU/ug)
Preparation and Storage
Ships ambient or refrigerated; after receipt store at 4°C for short term, -20°C for long term.
Related Product Information for HVEM-Fc active protein
HVEM belongs to the TNF Receptor superfamily of transmembrane proteins and plays a role in the activation of T-cells and other lymphocytes. It is expressed in various cells and tissues including spleen, thymus, lung, macrophages, and T-cells. HVEM activation induces a signaling cascade which results in induction of transcription factors NF-kappaB and AP-1. LIGHT (TNFSF14) and TNF-beta (TNFSF1) function as the ligands for HVEM, which can also bind specifically to herpes simplex virus glycoprotein D. Soluble HVEM can act as a ''receptor decoy'' resulting in inhibition of the activity of the HVEM ligands, LIGHT and TNF-beta.
Product Categories/Family for HVEM-Fc active protein
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Product Notes
The HVEM-Fc (Catalog #AAA14394) is an Active Protein produced from (BTI-Tn-5B1-4) Hi-5 Insect Cells and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's HVEM-Fc can be used in a range of immunoassay formats including, but not limited to, User optimized. Researchers should empirically determine the suitability of the HVEM-Fc for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. The amino acid sequence is listed below: Region of HVEM protein correspond ing to amino acids LPSCKEDEYP VGSECCPKCS PGYRVKEACG ELTGTVCEPC PPGTYIAHLN GLSKCLQCQM CDPAMGLRAS RNCSRTENAV CGCSPGHFCI VQDGDHCAAC RAYATSSPGQ RVQKGGTESQ DTLCQNCPPG TFSPNGTLEE CQHQTKRSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGK. Conjugated to Fc. It is sometimes possible for the material contained within the vial of "HVEM-Fc, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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