Hyaluronidase Active Protein | oHYAL 1 active protein

Hyaluronidase

Cat. Num. AAA142464

• Gene Names: HYAL3; LUCA3; HYAL-3; LUCA-3
• Synonyms: Hyaluronidase; HYAL1; Hyaluronidase-1; EC 3.2.1.35; Hyal-1; Hyaluronoglucosaminidase-1; LUCA-1; oHYAL 1 active protein

• Host: Bovine Testis
• Form/Format: The enzyme was lyophilized 1xPBS and 2% mannitol.; Sterile Filtered White lyophilized (freeze-dried) powder.
• Sequence Length: 463

• Solubility: It is recommended to reconstitute the lyophilized Hyaluronidase in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.
• Activity: 300 IU/mg.
• Preparation and Storage: Lyophilized Hyaluronidase although although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Hyaluronidase should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Related Product Information for oHYAL 1 active protein

Description: Hyaluronidase is an enzyme that temporarily and reversibly breaks down the polysaccharide, hyaluronic acid, which is found between the cells of connective tissue. Hyaluronic acid may be thought of as the "glue" that holds cells together. Hyaluronic acid is a mucopolysaccharide that exists in the human tissue matrix. It can constrain the diffusion of the extracellular fluid. Hyaluronidase makes the glucoseamine of the hyaluronic acid molecules hydrolyzed and depolymerized, thus decreases the viscosity of the body fluids and increases the flow and diffusion of the intercellular fluids. In this way the physic liquor, exudates or blood in local areas can be more easily diffused, and the drug can be more easily absorbed. Thus the local tissue tension and pains can be relieved. And it will also be easier for the edema and inflammatory exudates to be absorbed and dissolved. This product is a basic component of the articular cartilage. It can nourish, protect and maintain the functions of the joints.

Product Categories/Family for oHYAL 1 active protein

Enzymes; Natural Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 2935328
• NCBI GeneID: 8372
• NCBI Official Full Name: hyaluronidase
• NCBI Official Synonym Full Names: hyaluronoglucosaminidase 3
• NCBI Official Symbol: HYAL3
• NCBI Official Synonym Symbols: LUCA3; HYAL-3; LUCA-3
• NCBI Protein Information: hyaluronidase-3; lung carcinoma protein 3
• UniProt Protein Name: Hyaluronidase-3
• Protein Family: Hyaluronidase
• UniProt Gene Name: HYAL3
• UniProt Synonym Gene Names: LUCA3; Hyal-3; LuCa-3
• UniProt Entry Name: HYAL3_HUMAN

NCBI Description

This gene encodes a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Uniprot Description

HYAL3: a member of the hyaluronidase family. Hyaluronidases are endoglycosidase enzymes that degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. The regulated turnover of hyaluronan plays a critical role in many biological processes including cell proliferation, migration and differentiation. The encoded protein may also play an important role in sperm function. This gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression, and the expression of specific transcript variants may be indicative of tumor status. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and some isoforms may lack hyaluronidase activity. This gene overlaps and is on the same strand as N-acetyltransferase 6 (GCN5-related), and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]

Protein type: Secreted; Hydrolase; Secreted, signal peptide; EC 3.2.1.35

Chromosomal Location of Human Ortholog: 3p21.3

Cellular Component: lysosome; extracellular region; cytoplasmic vesicle

Molecular Function: viral receptor activity; hyaluronoglucuronidase activity; hyalurononglucosaminidase activity

Biological Process: response to antibiotic; cartilage development; response to virus; carbohydrate metabolic process; inflammatory response; hyaluronan catabolic process