Bovine Transmembrane protein 173 (TMEM173) ELISA Kit | TMEM173 elisa kit
Bovine Transmembrane protein 173 (TMEM173) ELISA Kit
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Uniprot Description
TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family.
Protein type: Membrane protein, integral; Endoplasmic reticulum; Membrane protein, multi-pass; Mitochondrial; Apoptosis
Chromosomal Location of Human Ortholog: 5q31.2
Cellular Component: Golgi apparatus; mitochondrial outer membrane; endoplasmic reticulum membrane; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; integral to membrane; plasma membrane; peroxisome
Molecular Function: identical protein binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; protein kinase binding; transcription factor binding
Biological Process: regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; apoptosis; positive regulation of transcription factor import into nucleus; positive regulation of interferon type I production; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; defense response to virus; activation of innate immune response; interferon-beta production
Disease: Sting-associated Vasculopathy, Infantile-onset
Research Articles on TMEM173
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Product Notes
The Bovine TMEM173 tmem173 (Catalog #AAA7202857) is an ELISA Kit and is intended for research purposes only. The product is available for immediate purchase. The AAA7202857 ELISA Kit recognizes Bovine TMEM173. It is sometimes possible for the material contained within the vial of "Transmembrane protein 173 (TMEM173), ELISA Kit" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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