BMP15 / Bone Morphogenetic Protein 15 Recombinant Protein | BMP15 recombinant protein

Human BMP15 / Bone Morphogenetic Protein 15 Recombinant Protein

• Gene Names: BMP15; ODG2; POF4; GDF9B
• Applications: ELISA, Western Blot
• Purity: >95% by SDS-PAGE
• Synonyms: BMP15 / Bone Morphogenetic Protein 15; Human BMP15 / Bone Morphogenetic Protein 15 Recombinant Protein; Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B; GDF9B; BMP15 recombinant protein

• Host: E Coli
• Purity/Purification: >95% by SDS-PAGE
• Form/Format: Liquid; 50mM NaH2PO4, 500mM NaCl Buffer with 500mM Imidazole, 10% Glycerol (PH8.0)
• Concentration: Reconstitution Dependent (varies by lot)
• Sequence Length: 392

• Applicable Applications for BMP15 recombinant protein: ELISA (EIA), Western Blot (WB), Antigen Protein (AP), Protein Array
• Species: Human
• Tag: His
• Subunit: Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.
• Entry Function: May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
• Preparation and Storage: Store at -20 degree C. Avoid repeated freezing and thawing.

NCBI and Uniprot Product Information

• NCBI GI #: 257743454
• NCBI GeneID: 9210
• NCBI Accession #: NP_005439.2
• NCBI GenBank Nucleotide #: NP_005439.2
• UniProt Accession #: O95972
• NCBI Official Full Name: bone morphogenetic protein 15 preproprotein
• NCBI Official Synonym Full Names: bone morphogenetic protein 15
• NCBI Official Symbol: BMP15
• NCBI Official Synonym Symbols: ODG2; POF4; GDF9B
• NCBI Protein Information: bone morphogenetic protein 15
• UniProt Protein Name: Bone morphogenetic protein 15
• Protein Family: Bone morphogenetic protein
• UniProt Gene Name: BMP15
• UniProt Synonym Gene Names: GDF9B; BMP-15; GDF-9B
• UniProt Entry Name: BMP15_HUMAN

NCBI Description

This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016]

Uniprot Description

BMP15: May be involved in follicular development. Oocyte- specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth. Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2); also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea. Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4). An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted; Cytokine

Chromosomal Location of Human Ortholog: Xp11.2

Cellular Component: extracellular space; cytoplasm

Molecular Function: growth factor activity; cytokine activity; transforming growth factor beta receptor binding

Biological Process: BMP signaling pathway; regulation of apoptosis; granulosa cell development; ovarian follicle development; positive regulation of transcription, DNA-dependent; regulation of MAPKKK cascade; female gamete generation; cell development

Disease: Ovarian Dysgenesis 2