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ZFP36L2 blocking peptide

ZFP36L2 Antibody (Center) Blocking Peptide

Gene Names
ZFP36L2; BRF2; ERF2; ERF-2; TIS11D; RNF162C
Synonyms
ZFP36L2; ZFP36L2 Antibody (Center) Blocking Peptide; Zinc finger protein 36; C3H1 type-like 2; ZFP36-like 2; Butyrate response factor 2; EGF-response factor 2; ERF-2; Protein TIS11D; BRF2; ERF2; RNF162C; TIS11D; ZFP36L2 blocking peptide
Ordering
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
494
Cellular Location
Cytoplasm. Nucleus. Note: Shuttles between the nucleus and the cytoplasm.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for ZFP36L2 blocking peptide
mRNA-binding protein that plays a key role in self- renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3'-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit- erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation (By similarity).

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
678
UniProt Accession #
Molecular Weight
51,063 Da
NCBI Official Full Name
Zinc finger protein 36, C3H1 type-like 2
NCBI Official Synonym Full Names
ZFP36 ring finger protein like 2
NCBI Official Symbol
ZFP36L2
NCBI Official Synonym Symbols
BRF2; ERF2; ERF-2; TIS11D; RNF162C
NCBI Protein Information
zinc finger protein 36, C3H1 type-like 2
UniProt Protein Name
Zinc finger protein 36, C3H1 type-like 2
UniProt Gene Name
ZFP36L2
UniProt Synonym Gene Names
BRF2; ERF2; RNF162C; TIS11D; ZFP36-like 2; ERF-2
UniProt Entry Name
TISD_HUMAN

NCBI Description

This gene is a member of the TIS11 family of early response genes. Family members are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. [provided by RefSeq, Jul 2008]

Uniprot Description

ZFP36L2: Probable regulatory protein involved in regulating the response to growth factors. RNA-binding protein that binds to 5'UUAUUUAUUU-3' core sequence. Binds to the class II AU-rich element (ARE) in the 3'-UTR of target mRNAs and promotes their deadenylation and degradation.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 2p22.3-p21

Cellular Component: cytoplasm; nucleus

Molecular Function: AU-rich element binding; transcription factor activity

Biological Process: cell proliferation; hemopoiesis; mRNA catabolic process; somatic stem cell division; somatic stem cell maintenance

Research Articles on ZFP36L2

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Product Notes

The ZFP36L2 zfp36l2 (Catalog #AAA9222773) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ZFP36L2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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