ZBTB17 blocking peptide

ZBTB17 Antibody (N-term) Blocking Peptide

• Gene Names: ZBTB17; MIZ-1; ZNF60; ZNF151; pHZ-67
• Synonyms: ZBTB17; ZBTB17 Antibody (N-term) Blocking Peptide; Zinc finger and BTB domain-containing protein 17; Myc-interacting zinc finger protein 1; Miz-1; Zinc finger protein 151; Zinc finger protein 60; MIZ1; ZNF151; ZNF60; ZBTB17 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 803

• Cellular Location: Nucleus
• Tissue Location: Expressed in germinal center B-cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ZBTB17 blocking peptide

Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation.

NCBI and Uniprot Product Information

• NCBI GI #: 62906906
• NCBI GeneID: 7709
• UniProt Accession #: Q13105; Q15932; Q5JYB2; Q9NUC9; A0AV07; B4DXB4; B7ZLQ9; F5H411
• Molecular Weight: 79,228 Da
• NCBI Official Full Name: Zinc finger and BTB domain-containing protein 17
• NCBI Official Synonym Full Names: zinc finger and BTB domain containing 17
• NCBI Official Symbol: ZBTB17
• NCBI Official Synonym Symbols: MIZ-1; ZNF60; ZNF151; pHZ-67
• NCBI Protein Information: zinc finger and BTB domain-containing protein 17
• UniProt Protein Name: Zinc finger and BTB domain-containing protein 17
• Protein Family: Zinc finger and BTB domain-containing protein
• UniProt Gene Name: ZBTB17
• UniProt Synonym Gene Names: MIZ1; ZNF151; ZNF60; Miz-1
• UniProt Entry Name: ZBT17_HUMAN

NCBI Description

This gene encodes a zinc finger protein involved in the regulation of c-myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

Uniprot Description

ZBTB17: a transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49 isoform 3/ZNF509S1. Belongs to the krueppel C2H2-type zinc-finger protein family. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Three isoforms of the human protein are produced by alternative splicing.

Protein type: Transcription factor; DNA-binding; C2H2-type zinc finger protein

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: nucleoplasm

Molecular Function: protein binding; transcription factor activity

Biological Process: negative regulation of cell cycle