WDR18 blocking peptide

WDR18 Antibody (C-term) Blocking peptide

• Gene Names: WDR18; Ipi3; R32184_1
• Synonyms: WDR18; WDR18 Antibody (C-term) Blocking peptide; WD repeat-containing protein 18; WDR18 blocking peptide

• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 432

• Cellular Location: Nucleus, nucleoplasm. Cytoplasm. Note: Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for WDR18 blocking peptide

May play a role during development (By similarity). Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.

NCBI and Uniprot Product Information

• NCBI GI #: 56243583
• NCBI GeneID: 57418
• NCBI Accession #: NP_077005.2
• NCBI GenBank Nucleotide #: NM_024100.3
• UniProt Accession #: Q9BV38; O60390; Q9BWR2
• Molecular Weight: 47,405 Da
• NCBI Official Full Name: WD repeat-containing protein 18
• NCBI Official Synonym Full Names: WD repeat domain 18
• NCBI Official Symbol: WDR18
• NCBI Official Synonym Symbols: Ipi3; R32184_1
• NCBI Protein Information: WD repeat-containing protein 18
• UniProt Protein Name: WD repeat-containing protein 18
• Protein Family: WD repeat-containing protein
• UniProt Gene Name: WDR18
• UniProt Entry Name: WDR18_HUMAN

NCBI Description

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. [provided by RefSeq, Jul 2008]

Uniprot Description

WDR18: a WD40 repeat protein. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: nucleoplasm

Molecular Function: protein binding

Biological Process: rRNA processing