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VNN3 blocking peptide

VNN3 Antibody (C-term) Blocking peptide

Gene Names
VNN3; HSA238982
Synonyms
VNN3; VNN3 Antibody (C-term) Blocking peptide; Vascular non-inflammatory molecule 3; Vanin-3; VNN3 blocking peptide
Ordering
Specificity
The synthetic peptide sequence used to generate the antibody was selected from the C-term region of VNN3. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
501
Cellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Note: According to PubMed:11491533, secreted.
Tissue Location
Widely expressed with higher expression in liver and blood. Expressed in differentiated keratinocytes in epidermis and in epithelial cells in dermis. Overexpressed in lesional psoriatic skin.
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for VNN3 blocking peptide
Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
UniProt Accession #
Molecular Weight
18,201 Da
NCBI Official Full Name
Vascular non-inflammatory molecule 3
NCBI Official Synonym Full Names
vanin 3
NCBI Official Symbol
VNN3
NCBI Official Synonym Symbols
HSA238982
NCBI Protein Information
vascular non-inflammatory molecule 3
UniProt Protein Name
Vascular non-inflammatory molecule 3
UniProt Gene Name
VNN3
UniProt Synonym Gene Names
Vanin-3
UniProt Entry Name
VNN3_HUMAN

NCBI Description

This gene is the central gene in a cluster of three vanin genes on chromosome 6q23-q24. Extensive alternative splicing has been described; the two most common variants are represented as RefSeqs. [provided by RefSeq, Apr 2014]

Uniprot Description

VNN3: Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine. Belongs to the CN hydrolase family. BTD/VNN subfamily. Induced by Th17/Th1 type cytokines, but not by Th2-type. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, GPI anchor; EC 3.5.1.92

Chromosomal Location of Human Ortholog: 6q23.2

Molecular Function: pantetheine hydrolase activity

Biological Process: biotin metabolic process; central nervous system development; pantothenate metabolic process

Research Articles on VNN3

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Product Notes

The VNN3 vnn3 (Catalog #AAA9220098) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "VNN3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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