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VAV2 blocking peptide

VAV2 (D138) Peptide

Gene Names
VAV2; VAV-2
Applications
Blocking
Purity
Synthetic peptide VAV2 (D138). (Note: the amino acid sequence is proprietary).
The purity is >98%.
Synonyms
VAV2; VAV2 (D138) Peptide; Guanine nucleotide exchange factor VAV2; VAV-2; VAV2 blocking peptide
Ordering
For Research Use Only!
Specificity
This peptide can be used with studies using MBS3002624 VAV2 (D138) pAb.
Purity/Purification
Synthetic peptide VAV2 (D138). (Note: the amino acid sequence is proprietary).
The purity is >98%.
Form/Format
1 mg/ml in DI water.
Sequence Length
878
Applicable Applications for VAV2 blocking peptide
Blocking
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Related Product Information for VAV2 blocking peptide
VAV2 is a ubiquitously expressed structural homolog of the VAV protooncogene that is expressed preferentially in hematopoetic cells. Both proteins are comprised of a Dbl homology (DH) domain with guanosine nucleotide exchange (GEF) activity exclusively directed towards Rho/Rac GTPases, a pleckstrin homology (PH) domain, a calponin-homology (CH) region, an acidic domain (AD) a zinc finger butterfly motif, two SH3 regions and one SH2 domain. GEF activity of RhoA family G proteins is induced by tyrosine phosphorylation in wild type VAV2, and is constitutively activated in N terminus deleted oncogene forms. Constitutive expression of a VAV2 oncoprotein may result in morphological alterations including highly enlarged cells in which karyokinesis and cytokinesis frequently are uncoupled.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
NCBI Official Full Name
guanine nucleotide exchange factor VAV2 isoform 1
NCBI Official Synonym Full Names
vav guanine nucleotide exchange factor 2
NCBI Official Symbol
VAV2
NCBI Official Synonym Symbols
VAV-2
NCBI Protein Information
guanine nucleotide exchange factor VAV2
UniProt Protein Name
Guanine nucleotide exchange factor VAV2
UniProt Gene Name
VAV2
UniProt Synonym Gene Names
VAV-2
UniProt Entry Name
VAV2_HUMAN

NCBI Description

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

Uniprot Description

VAV2: a proto-oncogenic guanine nucleotide exchange factors (GEF) of the Dbl family. A GEF for the Rho family of GTP binding proteins. Expressed in most tissues.

Protein type: GEFs, Rac/Rho; GEFs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 9q34.1

Cellular Component: plasma membrane; cytosol

Molecular Function: Rho guanyl-nucleotide exchange factor activity; protein binding; metal ion binding; guanyl-nucleotide exchange factor activity; epidermal growth factor receptor binding

Biological Process: lamellipodium biogenesis; axon guidance; platelet activation; cell migration; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of phosphoinositide 3-kinase activity; signal transduction; regulation of small GTPase mediated signal transduction; regulation of gene expression; small GTPase mediated signal transduction; regulation of blood coagulation; ephrin receptor signaling pathway; innate immune response; angiogenesis; blood coagulation; vascular endothelial growth factor receptor signaling pathway

Research Articles on VAV2

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Product Notes

The VAV2 vav2 (Catalog #AAA3002625) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's VAV2 can be used in a range of immunoassay formats including, but not limited to, Blocking. Researchers should empirically determine the suitability of the VAV2 vav2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "VAV2, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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