USP19 blocking peptide

USP19 Peptide

Cat. Num. AAA3006287

• Gene Names: USP19; ZMYND9
• Applications: Blocking
• Purity: Synthetic peptide USP19. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: USP19; USP19 Peptide; Ubiquitin carboxyl-terminal hydrolase 19; Deubiquitinating enzyme 19; Ubiquitin thioesterase 19; Ubiquitin-specific-processing protease 19; Zinc finger MYND domain-containing protein 9; KIAA0891; ZMYND9; USP19 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006286 USP19 pAb.
• Purity/Purification: Synthetic peptide USP19. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 1419

• Applicable Applications for USP19 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for USP19 blocking peptide

The ubiquitin (Ub) pathway involves three sequential enzymatic steps that facilitate the conjugation of Ub and Ub-like molecules to specific protein substrates. Through the use of a wide range of enzymes that can add or remove ubiquitin, the Ub pathway controls many intracellular processes such as signal transduction, transcriptional activation and cell cycle progression. Ubiquitin-specific-processing protease 19 (USP19), also known as ubiquitin carboxyl-terminal hydrolase 19, ubiquitin thioesterase 19 and deubiquitinating enzyme 19, is a 1318 amino acid member of the peptidase C19 family of proteins. USP19 is thought to be involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome. Four known isoforms of USP19 exist as a result of alternative splicing events.

NCBI and Uniprot Product Information

• NCBI GI #: 312596871
• NCBI GeneID: 10869
• NCBI Accession #: NP_001186089.1
• NCBI GenBank Nucleotide #: NP_001186089.1
• UniProt Accession #: O94966
• NCBI Official Full Name: ubiquitin carboxyl-terminal hydrolase 19 isoform 1
• NCBI Official Synonym Full Names: ubiquitin specific peptidase 19
• NCBI Official Symbol: USP19
• NCBI Official Synonym Symbols: ZMYND9
• NCBI Protein Information: ubiquitin carboxyl-terminal hydrolase 19
• UniProt Protein Name: Ubiquitin carboxyl-terminal hydrolase 19
• UniProt Gene Name: USP19
• UniProt Synonym Gene Names: KIAA0891; ZMYND9
• UniProt Entry Name: UBP19_HUMAN

NCBI Description

Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation, and signal transduction. This dynamic process, involving ubiquitin conjugating enzymes and deubiquitinating enzymes, adds and removes ubiquitin. Deubiquitinating enzymes are cysteine proteases that specifically cleave ubiquitin from ubiquitin-conjugated protein substrates. This protein is a ubiquitin protein ligase and plays a role in muscle wasting. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2017]

Uniprot Description

USP19: Deubiquitinating enzyme that regulates the degradation of various proteins. Deubiquitinates and prevents proteasomal degradation of RNF123 which in turn stimulates CDKN1B ubiquitin- dependent degradation thereby playing a role in cell proliferation. Involved in decreased protein synthesis in atrophying skeletal muscle. Modulates transcription of major myofibrillar proteins. Also involved in turnover of endoplasmic- reticulum-associated degradation (ERAD) substrates. Regulates the stability of BIRC2/c-IAP1 and BIRC3/c-IAP2 by preventing their ubiquitination. Required for cells to mount an appropriate response to hypoxia and rescues HIF1A from degradation in a non- catalytic manner. Plays an important role in 17 beta-estradiol (E2)-inhibited myogenesis. Decreases the levels of ubiquitinated proteins during skeletal muscle formation and acts to repress myogenesis. Exhibits a preference towards 'Lys-63'-linked Ubiquitin chains. Belongs to the peptidase C19 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.4.19.12; Ubiquitin-specific protease; Protease; Membrane protein, integral; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: endoplasmic reticulum membrane; integral to membrane; cytosol

Molecular Function: protein binding; metal ion binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: negative regulation of skeletal muscle development; ER-associated protein catabolic process; protein deubiquitination; regulation of protein stability