TUSC3 blocking peptide

TUSC3 (H153) Peptide

Cat. Num. AAA3002108

• Gene Names: TUSC3; M33; N33; MRT7; MRT22; MagT2; OST3A; D8S1992; SLC58A2
• Applications: Blocking
• Purity: Synthetic peptide TUSC3 (H153). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: TUSC3; TUSC3 (H153) Peptide; D8S1992; MGC13453; N33; OST3A; Protein N33; TUSC 3; TUSC3 blocking peptide

• Specificity: This peptide can be used with studies using MBS3002107 TUSC3 (H153) pAb.
• Purity/Purification: Synthetic peptide TUSC3 (H153). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 348

• Applicable Applications for TUSC3 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for TUSC3 blocking peptide

Made up of nearly 146 million bases, chromosome 8 encodes about 800 genes. Translocation of portions of chromosome 8 with amplifications of the c-Myc gene are found in some leukemias and lymphomas, and typically associated with a poor prognosis. Portions of chromosome 8 have been linked to schizophrenia and bipolar disorder. Trisomy 8, also known as Warkany syndrome 2, most often results in early miscarriage but is occasionally seen in a mosaic form in surviving patients who suffer to a varying degree from a number of symptoms including retarded mental and motor development, and certain facial and developmental defects. WRN is a DNA helicase encoded by chromosome 8 and shown defective in those with the early aging disorder Werner syndrome. Chromosome 8 is also associated with Pfeiffer syndrome, congenital hypothyroidism and Waardenburg syndrome.

NCBI and Uniprot Product Information

• NCBI GI #: 30410788
• NCBI GeneID: 7991
• NCBI Accession #: NP_006756.2
• NCBI GenBank Nucleotide #: NP_006756.2
• UniProt Accession #: Q13454
• NCBI Official Full Name: tumor suppressor candidate 3 isoform a
• NCBI Official Synonym Full Names: tumor suppressor candidate 3
• NCBI Official Symbol: TUSC3
• NCBI Official Synonym Symbols: M33; N33; MRT7; MRT22; MagT2; OST3A; D8S1992; SLC58A2
• NCBI Protein Information: tumor suppressor candidate 3
• UniProt Protein Name: Tumor suppressor candidate 3
• Protein Family: Tumor suppressor candidate
• UniProt Gene Name: TUSC3
• UniProt Synonym Gene Names: N33
• UniProt Entry Name: TUSC3_HUMAN

NCBI Description

This gene encodes a protein that has been associated with several biological functions including cellular magnesium uptake, protein glycosylation and embryonic development. This protein localizes to the endoplasmic reticulum and acts as a component of the oligosaccharyl transferase complex which is responsible for N-linked protein glycosylation. This gene is a candidate tumor suppressor gene. Homozygous mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation-7 and in the proliferation and invasiveness of several cancers including metastatic pancreatic cancer, ovarian cancer and glioblastoma multiform. [provided by RefSeq, Oct 2017]

Uniprot Description

TUSC3: Magnesium transporter. May be involved in N- glycosylation through its association with N-oligosaccharyl transferase. Defects in TUSC3 are the cause of mental retardation autosomal recessive type 7 (MRT7); also known as mental retardation non-syndromic autosomal recessive 7. Mental retardation is characterized by significantly sub-average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period. Non- syndromic mental retardation patients do not manifest other clinical signs. Belongs to the OST3/OST6 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 8p22

Cellular Component: endoplasmic reticulum membrane; mitochondrion; integral to plasma membrane; oligosaccharyl transferase complex

Molecular Function: dolichyl-diphosphooligosaccharide-protein glycotransferase activity; magnesium ion transmembrane transporter activity

Biological Process: cellular protein metabolic process; cell redox homeostasis; protein amino acid N-linked glycosylation; protein amino acid N-linked glycosylation via asparagine; post-translational protein modification; cognition; magnesium ion transport

Disease: Mental Retardation, Autosomal Recessive 7