TRIP13 blocking peptide

TRIP13 Peptide

Cat. Num. AAA3006275

• Applications: Blocking
• Purity: Synthetic peptide TRIP13. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: TRIP13; TRIP13 Peptide; Pachytene checkpoint protein 2 homolog; Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13; PCH2; TRIP13 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006274 TRIP13 pAb.
• Purity/Purification: Synthetic peptide TRIP13. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 432

• Applicable Applications for TRIP13 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for TRIP13 blocking peptide

Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner. TRIP13 (thyroid hormone receptor interactor 13), also called 16E1BP, is a transcription factor that interacts with the ligand binding domain of the thyroid receptor (TR) as well as a variety of target genes including human papilloma virus type 16 (HPV16) E1. Unlike most TRIP proteins which function only in the presence of hormones, TRIP13 does not require the presence of thyroid hormone to interact with TR. The association of TRIP13 with (HPV16) E1 suggests that TRIP13 may have tumor suppressor gene function. TRIP13 is a 432 amino acid protein with 2 different isoforms produced by alternative splicing.

NCBI and Uniprot Product Information

• NCBI GI #: 11321607
• NCBI Accession #: NP_004228.1
• NCBI GenBank Nucleotide #: NP_004228.1
• UniProt Accession #: Q15645
• NCBI Official Full Name: pachytene checkpoint protein 2 homolog isoform 1
• UniProt Protein Name: Pachytene checkpoint protein 2 homolog
• UniProt Gene Name: TRIP13
• UniProt Synonym Gene Names: PCH2; 16E1-BP; HPV16 E1 protein-binding protein; TR-interacting protein 13; TRIP-13
• UniProt Entry Name: PCH2_HUMAN

Uniprot Description

TRIP13: Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double- strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Belongs to the AAA ATPase family. PCH2 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 5p15.33

Cellular Component: male germ cell nucleus; nucleus

Molecular Function: identical protein binding; protein binding; transcription cofactor activity; ATP binding

Biological Process: oogenesis; transcription from RNA polymerase II promoter; synaptonemal complex assembly; male meiosis I; meiotic recombination; double-strand break repair; spermatogenesis; oocyte maturation; spermatid development; female meiosis I