TRIM25 blocking peptide

TRIM25 Peptide

Gene Names

TRIM25; EFP; Z147; RNF147; ZNF147

Applications

Blocking (BL)

Synonyms

TRIM25; TRIM25 Peptide; EFP; Z147; RNF147; ZNF147; Estrogen-responsive finger protein; tripartite motif-containing 25; TRIM25 blocking peptide

Ordering
Cat. Num. AAA151801 For Research Use Only!

Form/Format

Liquid

Concentration

200 ug/mL (varies by lot)

Sequence Length

630

Applicable Applications for TRIM25 blocking peptide

Blocking (BL)

Application Notes

TRIM25 peptide is used for blocking the activity of TRIM25 antibody.

Species

Human

Buffer

PBS pH 7.2 (10 mM NaH2PO4, 10 mM Na2HPO4, 130 mM NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide

Location

15 amino acids near the amino terminus of human TRIM25.

Preparation and Storage

Store TRIM25 peptide at -20 degree C, stable for one year.

NCBI and Uniprot Product Information

NCBI GI #

68160937

NCBI GeneID

7706

NCBI Accession #

NP_005073

NCBI GenBank Nucleotide #

NM_005082.4

UniProt Accession #

Q14258

Molecular Weight

70,973 Da

NCBI Official Full Name

E3 ubiquitin/ISG15 ligase TRIM25

NCBI Official Synonym Full Names

tripartite motif containing 25

NCBI Official Symbol

TRIM25

NCBI Official Synonym Symbols

EFP; Z147; RNF147; ZNF147

NCBI Protein Information

E3 ubiquitin/ISG15 ligase TRIM25; RING finger protein 147; zinc finger protein-147; tripartite motif-containing 25; tripartite motif protein TRIM25; estrogen-responsive finger protein; tripartite motif-containing protein 25; ubiquitin/ISG15-conjugating enzyme TRIM25; zinc finger protein 147 (estrogen-responsive finger protein)

UniProt Protein Name

E3 ubiquitin/ISG15 ligase TRIM25

Protein Family

E3 ubiquitin/ISG15 ligase

UniProt Gene Name

TRIM25

UniProt Synonym Gene Names

EFP; RNF147; ZNF147

UniProt Entry Name

TRI25_HUMAN

NCBI Description

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to the cytoplasm. The presence of potential DNA-binding and dimerization-transactivation domains suggests that this protein may act as a transcription factor, similar to several other members of the TRIM family. Expression of the gene is upregulated in response to estrogen, and it is thought to mediate estrogen actions in breast cancer as a primary response gene. [provided by RefSeq, Jul 2008]

Uniprot Description

TRIM25: a ubiquitous protein that mediates estrogen action in various target organs. Contains one RING-type zinc finger and one SPRY domain.

Protein type: EC 6.3.2.19; Nuclear receptor co-regulator; Transcription factor; Ubiquitin conjugating system; EC 6.3.2.n3; Ubiquitin ligase; Ligase

Chromosomal Location of Human Ortholog: 17q23.2

Cellular Component: nucleoplasm; cytoplasm; cytosol

Molecular Function: protein binding; acid-amino acid ligase activity; zinc ion binding; transcription factor activity

Biological Process: response to vitamin D; positive regulation of I-kappaB kinase/NF-kappaB cascade; viral reproduction; response to estrogen stimulus; negative regulation of virion penetration into host cell; cytokine and chemokine mediated signaling pathway; protein ubiquitination; innate immune response; positive regulation of transcription factor activity; regulation of virion penetration into host cell; defense response to virus; negative regulation of interferon type I production; activation of NF-kappaB transcription factor

Research Articles on TRIM25

1. Our data uncovers a previously unknown functional link between gp78 and TRIM25 and provides mechanistic insight into gp78-mediated protein ubiquitylation.

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Product Notes

The TRIM25 trim25 (Catalog #AAA151801) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TRIM25 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). TRIM25 peptide is used for blocking the activity of TRIM25 antibody. Researchers should empirically determine the suitability of the TRIM25 trim25 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TRIM25, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.