TLX1 blocking peptide
TLX1 Peptide
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Uniprot Description
TLX1: Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. A chromosomal aberration involving TLX1 may be a cause of a form of T-cell acute lymphoblastic leukemia (T-ALL). Translocation t(10;14)(q24;q11) with TCRD. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Oncoprotein; DNA-binding
Chromosomal Location of Human Ortholog: 10q24
Cellular Component: nucleus
Molecular Function: protein binding; protein heterodimerization activity; sequence-specific DNA binding
Biological Process: neuron differentiation; spleen development; organ formation; central nervous system development; cell fate commitment; positive regulation of cell proliferation; positive regulation of transcription from RNA polymerase II promoter
Research Articles on TLX1
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Product Notes
The TLX1 tlx1 (Catalog #AAA153852) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's TLX1 can be used in a range of immunoassay formats including, but not limited to, Blocking (BL). TLX1 peptide is used for blocking the activity of TLX1 antibody. It usually blocks the antibody activity completely in Western blot by incubating the peptide with equal volume of antibody for 30 min at 37 degree C. Researchers should empirically determine the suitability of the TLX1 tlx1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TLX1, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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