Tlr5 blocking peptide

Mouse TLR5 Antibody (C-term) Blocking Peptide

• Synonyms: TLR5; Mouse TLR5 Antibody (C-term) Blocking Peptide; Toll-like receptor 5; Tlr5; Tlr5 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human Mouse TLR5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 859

• Cellular Location: Membrane; Single-pass type I membrane protein
• Tissue Location: Highly expressed in liver. Detected in lung and at very low levels in most other tissues
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Tlr5 blocking peptide

Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 20140822
• NCBI GeneID: 53791
• UniProt Accession #: Q9JLF7
• Molecular Weight: 97,627 Da
• NCBI Official Full Name: Toll-like receptor 5
• NCBI Official Synonym Full Names: toll-like receptor 5
• NCBI Official Symbol: Tlr5
• NCBI Protein Information: toll-like receptor 5
• UniProt Protein Name: Toll-like receptor 5
• Protein Family: Toll-like receptor
• UniProt Gene Name: Tlr5
• UniProt Entry Name: TLR5_MOUSE

Uniprot Description

TLR5: Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Genetic variation in TLR5 is associated with resistance to systemic lupus erythematosus type 1 (SLEB1). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a complex genetic basis. SLE is an inflammatory, and often febrile multisystemic disorder of connective tissue characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. Belongs to the Toll-like receptor family.

Protein type: Membrane protein, integral; Receptor, misc.

Cellular Component: integral to plasma membrane; membrane

Molecular Function: interleukin-1 receptor binding; protein binding; receptor activity

Biological Process: defense response to Gram-negative bacterium; inflammatory response; positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; positive regulation of toll-like receptor signaling pathway; toll-like receptor signaling pathway