THOC7 blocking peptide

THOC7 Antibody (C-term) Blocking Peptide

• Gene Names: THOC7; fSAP24; hTREX30; NIF3L1BP1
• Synonyms: THOC7; THOC7 Antibody (C-term) Blocking Peptide; THO complex subunit 7 homolog; Functional spliceosome-associated protein 24; fSAP24; Ngg1-interacting factor 3-like protein 1-binding protein 1; NIF3L1-binding protein 1; hTREX30; NIF3L1BP1; THOC7 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 204

• Cellular Location: Cytoplasm. Nucleus. Nucleus speckle. Note: Interaction with THOC5 is required for nuclear localization
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for THOC7 blocking peptide

Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

NCBI and Uniprot Product Information

• NCBI GI #: 229462996
• NCBI GeneID: 80145
• UniProt Accession #: Q6I9Y2; Q6P1L3; Q8WUF2; Q9H5H0
• Molecular Weight: 23,743 Da
• NCBI Official Full Name: THO complex subunit 7 homolog
• NCBI Official Synonym Full Names: THO complex 7
• NCBI Official Symbol: THOC7
• NCBI Official Synonym Symbols: fSAP24; hTREX30; NIF3L1BP1
• NCBI Protein Information: THO complex subunit 7 homolog
• UniProt Protein Name: THO complex subunit 7 homolog
• Protein Family: THO complex
• UniProt Gene Name: THOC7
• UniProt Synonym Gene Names: NIF3L1BP1; fSAP24; NIF3L1-binding protein 1
• UniProt Entry Name: THOC7_HUMAN

Uniprot Description

THOC7: Component of the THO subcomplex of the TREX complex. The TREX complex specifically associates with spliced mRNA and not with unspliced pre-mRNA. It is recruited to spliced mRNAs by a transcription-independent mechanism. Binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export. The recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. DDX39B functions as a bridge between ALYREF/THOC4 and the THO complex. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. The recruitment of the TREX complex to the intronless viral mRNA occurs via an interaction between KSHV ORF57 protein and ALYREF/THOC4. Belongs to the THOC7 family.

Protein type: RNA splicing; Spliceosome

Chromosomal Location of Human Ortholog: 3p14.1

Cellular Component: cytoplasm; nuclear chromosome, telomeric region; nucleoplasm; nucleus

Molecular Function: nucleic acid binding; protein binding

Biological Process: intronless viral mRNA export from host nucleus; mRNA 3'-end processing; mRNA export from nucleus; RNA elongation from RNA polymerase II promoter; RNA export from nucleus; termination of RNA polymerase II transcription