TCF7L1 blocking peptide

TCF7L1 Blocking Peptide (N-term)

• Gene Names: TCF7L1; TCF3; TCF-3
• Synonyms: TCF7L1; TCF7L1 Blocking Peptide (N-term); Transcription factor 7-like 1; HMG box transcription factor 3; TCF-3; TCF3; TCF7L1 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 588

• Cellular Location: Nucleus.
• Tissue Location: Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for TCF7L1 blocking peptide

Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.

NCBI and Uniprot Product Information

• NCBI GI #: 29337134
• NCBI GeneID: 83439
• UniProt Accession #: Q9HCS4; Q53R97; Q6PD70; Q9NP00
• Molecular Weight: 62,631 Da
• NCBI Official Full Name: Transcription factor 7-like 1
• NCBI Official Synonym Full Names: transcription factor 7 like 1
• NCBI Official Symbol: TCF7L1
• NCBI Official Synonym Symbols: TCF3; TCF-3
• NCBI Protein Information: transcription factor 7-like 1
• UniProt Protein Name: Transcription factor 7-like 1
• Protein Family: Transcription factor
• UniProt Gene Name: TCF7L1
• UniProt Synonym Gene Names: TCF3; TCF-3
• UniProt Entry Name: TF7L1_HUMAN

NCBI Description

This gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq, Nov 2010]

Uniprot Description

TCF3: Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. Belongs to the TCF/LEF family.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 2p11.2

Cellular Component: nucleoplasm; transcription factor complex

Molecular Function: beta-catenin binding; sequence-specific DNA binding

Biological Process: regulation of transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin