SYVN1 blocking peptide

SYVN1 Blocking Peptide

Cat. Num. AAA9620940

• Gene Names: SYVN1; DER3; HRD1
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: SYVN1; SYVN1 Blocking Peptide; 1200010C09Rik; DER3; E3 ubiquitin-protein ligase synoviolin; HMG coA reductase degradation 1 homolog; HRD1; KIAA1810; MGC40372; OTTHUMP00000230429; OTTHUMP00000230430; OTTHUMP00000230431; OTTHUMP00000230432; Synovial apoptosis inhibitor 1; synoviolin; Synoviolin 1 isoform b; SYNOVIOLIN; SYVN1_HUMAN; SYVN1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SYVN1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SYVN1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 27436925
• NCBI GeneID: 84447
• NCBI Accession #: NP_115807.1
• NCBI GenBank Nucleotide #: NM_032431.2
• UniProt Accession #: Q86TM6; Q8N3K3; Q8N6E8; Q96JL5; Q96PK3
• Molecular Weight: 67,614 Da
• NCBI Official Full Name: E3 ubiquitin-protein ligase synoviolin isoform a
• NCBI Official Synonym Full Names: synovial apoptosis inhibitor 1, synoviolin
• NCBI Official Symbol: SYVN1
• NCBI Official Synonym Symbols: DER3; HRD1
• NCBI Protein Information: E3 ubiquitin-protein ligase synoviolin; HMG-coA reductase degradation 1 homolog
• UniProt Protein Name: E3 ubiquitin-protein ligase synoviolin
• Protein Family: E3 ubiquitin-protein ligase
• UniProt Gene Name: SYVN1
• UniProt Synonym Gene Names: HRD1; KIAA1810

NCBI Description

This gene encodes a protein involved in endoplasmic reticulum (ER)-associated degradation. The encoded protein removes unfolded proteins, accumulated during ER stress, by retrograde transport to the cytosol from the ER. This protein also uses the ubiquitin-proteasome system for additional degradation of unfolded proteins. Sequence analysis identified two transcript variants that encode different isoforms. [provided by RefSeq, May 2011]

Uniprot Description

Acts as an E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated UBC7 E2 ligase and transfers it to substrates, promoting their degradation (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins (PubMed:12459480, PubMed:12646171, PubMed:12975321, PubMed:14593114, PubMed:16289116, PubMed:16847254, PubMed:17059562, PubMed:17141218, PubMed:17170702, PubMed:22607976, PubMed:26471130). Also promotes the degradation of normal but naturally short-lived proteins such as SGK. Protects cells from ER stress-induced apoptosis. Protects neurons from apoptosis induced by polyglutamine-expanded huntingtin (HTT) or unfolded GPR37 by promoting their degradation (PubMed:17141218). Sequesters p53/TP53 in the cytoplasm and promotes its degradation, thereby negatively regulating its biological function in transcription, cell cycle regulation and apoptosis (PubMed:17170702). Mediates the ubiquitination and subsequent degradation of cytoplasmic NFE2L1 ().