SUZ12 blocking peptide

SUZ12 Blocking Peptide (C-term)

Gene Names

SUZ12; CHET9; JJAZ1

Synonyms

SUZ12; SUZ12 Blocking Peptide (C-term); Polycomb protein SUZ12; Chromatin precipitated E2F target 9 protein; ChET 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog; CHET9; JJAZ1; KIAA0160; SUZ12 blocking peptide

Ordering

Form/Format

Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.

Sequence Length

739

Cellular Location

Nucleus.

Tissue Location

Overexpressed in breast and colon cancer.

Preparation and Storage

Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SUZ12 blocking peptide

Polycomb group (PcG) protein. Component of the PRC2/EED- EZH2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene. The PRC2/EED-EZH2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems. Genes repressed by the PRC2/EED-EZH2 complex include HOXC8, HOXA9, MYT1 and CDKN2A.

NCBI and Uniprot Product Information

NCBI GI #

116242808

NCBI GeneID

23512

UniProt Accession #

Q15022; Q96BD9

Molecular Weight

83,055 Da

NCBI Official Full Name

Polycomb protein SUZ12

NCBI Official Synonym Full Names

SUZ12 polycomb repressive complex 2 subunit

NCBI Official Symbol

SUZ12

NCBI Official Synonym Symbols

CHET9; JJAZ1

NCBI Protein Information

polycomb protein SUZ12

UniProt Protein Name

Polycomb protein SUZ12

Protein Family

Polycomb protein

UniProt Gene Name

SUZ12

UniProt Synonym Gene Names

CHET9; JJAZ1; KIAA0160; ChET 9 protein

UniProt Entry Name

SUZ12_HUMAN

NCBI Description

This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]

Uniprot Description

SUZ12: a zinc finger protein. A breakpoint translocation of the cognate gene with JAZF1 has been reported in endometrial stromal sarcoma.

Protein type: Oncoprotein; C2H2-type zinc finger protein; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: ESC/E(Z) complex; nucleolus; nucleoplasm; nucleus

Molecular Function: histone methyltransferase activity; methylated histone residue binding; protein binding

Biological Process: negative regulation of cell differentiation; negative regulation of gene expression, epigenetic

Research Articles on SUZ12

1. Data show that RAS protein activation was the initiating oncogenic event, with polycomb repressive complex 2 (PRC2) subunits impairment being a secondary event.

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Product Notes

The SUZ12 suz12 (Catalog #AAA9228989) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SUZ12, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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SUZ12 blocking peptide