STAT5A blocking peptide

STAT5A Blocking Peptide (C-term)

• Gene Names: STAT5A; MGF; STAT5
• Synonyms: STAT5A; STAT5A Blocking Peptide (C-term); Signal transducer and activator of transcription 5A; STAT5; STAT5A blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 730-745 of HUMAN STAT5A
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 794

• Cellular Location: Cytoplasm. Nucleus. Note: Translocated into the nucleus in response to phosphorylation
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for STAT5A blocking peptide

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Mediates cellular responses to ERBB4. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the GAS element and activates PRL-induced transcription. Regulates the expression of milk proteins during lactation.

NCBI and Uniprot Product Information

• NCBI GI #: 1174462
• NCBI GeneID: 6776
• UniProt Accession #: P42229; Q1KLZ6
• Molecular Weight: 86,949 Da
• NCBI Official Full Name: Signal transducer and activator of transcription 5A
• NCBI Official Synonym Full Names: signal transducer and activator of transcription 5A
• NCBI Official Symbol: STAT5A
• NCBI Official Synonym Symbols: MGF; STAT5
• NCBI Protein Information: signal transducer and activator of transcription 5A
• UniProt Protein Name: Signal transducer and activator of transcription 5A
• Protein Family: Signal transducer and activator of transcription
• UniProt Gene Name: STAT5A
• UniProt Synonym Gene Names: STAT5
• UniProt Entry Name: STA5A_HUMAN

NCBI Description

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Uniprot Description

STAT5A: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of many cytokines and growth-factor receptors. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 fusion protein is essential for the tumorigenesis. Induces the expression of BCL2L1/BCL-X(L) in the mouse, suggesting an antiapoptotic function of this protein. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described.

Protein type: Oncoprotein; Motility/polarity/chemotaxis; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 17q11.2

Cellular Component: cytoplasm; cytosol; nucleoplasm

Molecular Function: protein binding; protein-tyrosine kinase activity

Biological Process: 2-oxoglutarate metabolic process; allantoin metabolic process; citrate metabolic process; creatine metabolic process; creatinine metabolic process; fatty acid metabolic process; isoleucine metabolic process; JAK-STAT cascade; oxaloacetate metabolic process; positive regulation of blood vessel endothelial cell migration; positive regulation of endothelial cell proliferation; regulation of multicellular organism growth; regulation of transcription from RNA polymerase II promoter; succinate metabolic process; taurine metabolic process; valine metabolic process