SPRR1B blocking peptide

SPRR1B Antibody (C-term) Blocking Peptide

• Gene Names: SPRR1B; SPRR1; GADD33; SPR-IB; CORNIFIN
• Synonyms: SPRR1B; SPRR1B Antibody (C-term) Blocking Peptide; Cornifin-B; 149 kDa pancornulin; Small proline-rich protein IB; SPR-IB; SPRR1B blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SPRR1B. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 89

• Cellular Location: Cytoplasm.
• Tissue Location: Suprabasal layers of squamous-differentiated tissues such as epidermis, esophagus, tongue and trachea
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SPRR1B blocking peptide

Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage.

NCBI and Uniprot Product Information

• NCBI GI #: 84028265
• NCBI GeneID: 6699
• UniProt Accession #: P22528; P22529; P22530; Q5T524; B2R5H7
• Molecular Weight: 9,888 Da
• NCBI Official Full Name: Cornifin-B
• NCBI Official Synonym Full Names: small proline rich protein 1B
• NCBI Official Symbol: SPRR1B
• NCBI Official Synonym Symbols: SPRR1; GADD33; SPR-IB; CORNIFIN
• NCBI Protein Information: cornifin-B
• UniProt Protein Name: Cornifin-B
• Protein Family: Cornifin
• UniProt Gene Name: SPRR1B
• UniProt Synonym Gene Names: SPR-IB
• UniProt Entry Name: SPR1B_HUMAN

NCBI Description

The protein encoded by this gene is an envelope protein of keratinocytes. The encoded protein is crosslinked to membrane proteins by transglutaminase, forming an insoluble layer under the plasma membrane. This protein is proline-rich and contains several tandem amino acid repeats. [provided by RefSeq, Nov 2015]

Uniprot Description

SPRR1B: Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane. Can function as both amine donor and acceptor in transglutaminase-mediated cross- linkage. Belongs to the cornifin (SPRR) family.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q21-q22

Cellular Component: cornified envelope

Molecular Function: protein binding, bridging; structural molecule activity

Biological Process: epidermis development; keratinocyte differentiation; peptide cross-linking