SPPL3 blocking peptide
SPPL3 Antibody (N-term) Blocking Peptide
NCBI and Uniprot Product Information
Uniprot Description
SPPL3: Intramembrane-cleaving aspartic protease (I-CLiP) that cleaves type II membrane signal peptides in the hydrophobic plane of the membrane. Belongs to the peptidase A22B family. 3 isoforms of the human protein are produced by alternative splicing.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; EC 3.4.23.-; Protease
Chromosomal Location of Human Ortholog: 12q24.31
Cellular Component: ER-Golgi intermediate compartment membrane; intracellular membrane-bound organelle; lysosomal membrane; membrane; plasma membrane; rough endoplasmic reticulum
Molecular Function: aspartic endopeptidase activity, intramembrane cleaving; protein binding; protein homodimerization activity
Biological Process: elevation of cytosolic calcium ion concentration; membrane protein ectodomain proteolysis; membrane protein proteolysis; positive regulation of NFAT protein import into nucleus; positive regulation of protein amino acid dephosphorylation; positive regulation of protein binding; signal peptide processing; T cell receptor signaling pathway
Research Articles on SPPL3
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Product Notes
The SPPL3 sppl3 (Catalog #AAA9226049) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SPPL3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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