SOX7 blocking peptide

SOX7 Blocking Peptide (Center)

• Synonyms: SOX7; SOX7 Blocking Peptide (Center); Transcription factor SOX-7; SOX7 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 224-238 of HUMAN SOX7
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 388

• Cellular Location: Nucleus. Cytoplasm
• Tissue Location: Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SOX7 blocking peptide

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity). May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity). Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity). Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.

NCBI and Uniprot Product Information

• NCBI GI #: 20532272
• NCBI GeneID: 83595
• UniProt Accession #: Q9BT81; Q53YD0; B4DKV0
• Molecular Weight: 48,522 Da
• NCBI Official Full Name: Transcription factor SOX-7
• NCBI Official Synonym Full Names: SRY-box 7
• NCBI Official Symbol: SOX7
• NCBI Protein Information: transcription factor SOX-7
• UniProt Protein Name: Transcription factor SOX-7
• Protein Family: Transcription factor
• UniProt Gene Name: SOX7
• UniProt Entry Name: SOX7_HUMAN

NCBI Description

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The protein may play a role in tumorigenesis. A similar protein in mice is involved in the regulation of the wingless-type MMTV integration site family (Wnt) pathway. [provided by RefSeq, Jul 2008]

Uniprot Description

SOX7: Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors. May be required for the survival of both hematopoietic and endothelial precursors during specification. Competes with GATA4 for binding and activation of the FGF3 promoter. Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'.

Protein type: Transcription factor; DNA-binding

Chromosomal Location of Human Ortholog: 8p23.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: protein binding; transcription factor activity

Biological Process: endoderm formation; negative regulation of cell proliferation; negative regulation of transcription, DNA-dependent; positive regulation of caspase activity