SNX33 blocking peptide

SNX33 Antibody (C-term) Blocking Peptide

• Gene Names: SNX33; SNX30; SH3PX3; SH3PXD3C
• Synonyms: SNX33; SNX33 Antibody (C-term) Blocking Peptide; Sorting nexin-33; SH3 and PX domain-containing protein 3; SH3PX3; SH3PXD3C; SNX30; SNX33 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 574

• Cellular Location: Cytoplasm, cytosol. Membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Note: Primarily cytosolic, but a minor proportion is membrane-bound (PubMed:18353773). Not associated with membranes (PubMed:21048941).
• Tissue Location: Detected in heart and pancreas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SNX33 blocking peptide

Plays a role in the reorganization of the cytoskeleton, endocytosis and cellular vesicle trafficking via its interactions with membranes, WASL, DNM1 and DNM2. Acts both during interphase and at the end of mitotic cell divisions. Required for efficient progress through mitosis and cytokinesis. Required for normal formation of the cleavage furrow at the end of mitosis. Modulates endocytosis of cell-surface proteins, such as APP and PRNP; this then modulates the secretion of APP and PRNP peptides. Promotes membrane tubulation (in vitro). May promote the formation of macropinosomes.

NCBI and Uniprot Product Information

• NCBI GI #: 74751538
• NCBI GeneID: 257364
• UniProt Accession #: Q8WV41; B1NM17
• Molecular Weight: 65,265 Da
• NCBI Official Full Name: Sorting nexin-33
• NCBI Official Synonym Full Names: sorting nexin 33
• NCBI Official Symbol: SNX33
• NCBI Official Synonym Symbols: SNX30; SH3PX3; SH3PXD3C
• NCBI Protein Information: sorting nexin-33
• UniProt Protein Name: Sorting nexin-33
• Protein Family: Sorting nexin
• UniProt Gene Name: SNX33
• UniProt Synonym Gene Names: SH3PX3; SH3PXD3C; SNX30
• UniProt Entry Name: SNX33_HUMAN

NCBI Description

The protein encoded by this gene is involved in cytoskeletal reorganization, vesicle trafficking, endocytosis, and mitosis. The encoded protein is essential for the creation of the cleavage furrow during mitosis and for completion of mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

Uniprot Description

SNX33: Belongs to the sorting nexin family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 15q24.2

Cellular Component: cytoplasmic membrane-bound vesicle; cytosol; endosome; extrinsic to membrane; membrane

Molecular Function: identical protein binding; phosphoinositide binding; protein binding

Biological Process: cytokinesis after mitosis; endocytosis; endosome organization and biogenesis; endosome transport; negative regulation of endocytosis; positive regulation of membrane protein ectodomain proteolysis; protein import; vesicle organization and biogenesis