SMN1 blocking peptide

SMN1 Blocking Peptide

Cat. Num. AAA9620202

• Gene Names: GEMIN2; SIP1; SIP1-delta
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: SMN1; SMN1 Blocking Peptide; Component of gems 2; Gem (nuclear organelle) associated protein 2; Gem associated protein 2; GEMI2_HUMAN; Gemin-2; gemin2; SIP 1; SIP-1; SIP1; SIP1 delta; SIP1-delta; SMN interacting protein 1; SMN interacting protein 1 delta; SMN-interacting protein 1; Survival interacting protein 1; Survival of motor neuron protein interacting protein 1; Survival of motor neuron protein-interacting protein 1; SMN1 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SMN1 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SMN1 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 57165350
• NCBI GeneID: 8487
• NCBI Accession #: NP_001009182.1
• NCBI GenBank Nucleotide #: NM_001009182.1
• UniProt Accession #: O14893; Q2M3B3; Q9H4F5; Q9NS77; Q9NS78; Q9NS79; B2R9W8
• Molecular Weight: 4,826 Da
• NCBI Official Full Name: gem-associated protein 2 isoform beta
• NCBI Official Synonym Full Names: gem (nuclear organelle) associated protein 2
• NCBI Official Symbol: GEMIN2
• NCBI Official Synonym Symbols: SIP1; SIP1-delta
• NCBI Protein Information: gem-associated protein 2; gemin-2; component of gems 2; SMN interacting protein 1-delta; survival of motor neuron protein interacting protein 1
• UniProt Protein Name: Gem-associated protein 2
• Protein Family: Survival motor neuron protein
• UniProt Gene Name: GEMIN2
• UniProt Synonym Gene Names: SIP1; Gemin-2; SMN-interacting protein 1
• UniProt Entry Name: GEMI2_HUMAN

NCBI Description

This gene encodes one of the proteins found in the SMN complex, which consists of several gemin proteins and the protein known as the survival of motor neuron protein. The SMN complex is localized to a subnuclear compartment called gems (gemini of coiled bodies) and is required for assembly of spliceosomal snRNPs and for pre-mRNA splicing. This protein interacts directly with the survival of motor neuron protein and it is required for formation of the SMN complex. A knockout mouse targeting the mouse homolog of this gene exhibited disrupted snRNP assembly and motor neuron degeneration. [provided by RefSeq, Aug 2011]

Uniprot Description

SIP1: The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. Belongs to the gemin-2 family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing

Chromosomal Location of Human Ortholog: 14q13

Cellular Component: nucleoplasm; spliceosome; cytoplasm; nucleolus; SMN complex; cytosol; nucleus

Molecular Function: protein binding

Biological Process: RNA splicing, via transesterification reactions; spliceosomal snRNP biogenesis; RNA splicing; spliceosome assembly; gene expression; mRNA processing