SLC6A8 blocking peptide

SLC6A8 Peptide

Cat. Num. AAA3006220

• Gene Names: SLC6A8; CRT; CT1; CRTR; CTR5; CCDS1
• Applications: Blocking
• Purity: Synthetic peptide SLC6A8. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SLC6A8; SLC6A8 Peptide; Sodium- and chloride-dependent creatine transporter 1; CT1; Creatine transporter 1; Solute carrier family 6 member 8; SLC6A8 blocking peptide

• Specificity: This peptide can be used with studies using MBS3006219 SLC6A8 pAb.
• Purity/Purification: Synthetic peptide SLC6A8. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 625

• Applicable Applications for SLC6A8 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SLC6A8 blocking peptide

SLC6A8 (solute carrier family 6 member 8), also known as CT1 (creatine transporter 1), CRT or CRTR, is a 635 amino acid multi-pass plasma membrane protein that belongs to the sodium/neurotransporter (SNF) family. Expressed in a variety of tissues including kidney, skeletal muscle, heart, brain, prostate, testis and colon, SLC6A8 functions to transport creatine into and out of cells, specifically those found in brain and muscle tissue. Creatine, an organic acid, occurs naturally and is essential for supplying the energy needed for proper muscle and nerve function. Defects in the gene encoding SLC6A8 lead to cerebral creatine deficiency and are the cause of X-linked creatine deficiency syndrome, a rare disorder characterized by facial anomalies, seizures and mental retardation. Multiple isoforms of SLC6A8 exist due to alternative splicing events.

NCBI and Uniprot Product Information

• NCBI GI #: 218563756
• NCBI GeneID: 6535
• NCBI Accession #: NP_001136277.1
• NCBI GenBank Nucleotide #: NP_001136277.1
• UniProt Accession #: P48029
• NCBI Official Full Name: sodium- and chloride-dependent creatine transporter 1 isoform 2
• NCBI Official Synonym Full Names: solute carrier family 6 member 8
• NCBI Official Symbol: SLC6A8
• NCBI Official Synonym Symbols: CRT; CT1; CRTR; CTR5; CCDS1
• NCBI Protein Information: sodium- and chloride-dependent creatine transporter 1
• UniProt Protein Name: Sodium- and chloride-dependent creatine transporter 1
• Protein Family: Sodium- and chloride-dependent creatine transporter
• UniProt Gene Name: SLC6A8
• UniProt Synonym Gene Names: CT1
• UniProt Entry Name: SC6A8_HUMAN

NCBI Description

The protein encoded by this gene is a plasma membrane protein whose function is to transport creatine into and out of cells. Defects in this gene can result in X-linked creatine deficiency syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]

Uniprot Description

SLC6A8: Required for the uptake of creatine in muscles and brain. Defects in SLC6A8 are the cause of X-linked creatine deficiency syndrome (XL-CDS). XL-CDS causes developmental delay, hypotonia, mental retardation, seizures, short stature and midface hypoplasia. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Motility/polarity/chemotaxis; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: integral to plasma membrane; plasma membrane; integral to membrane

Molecular Function: creatine transporter activity; neurotransmitter:sodium symporter activity; creatine:sodium symporter activity

Biological Process: muscle contraction; neurotransmitter transport; transport; sodium ion transport; creatine metabolic process; creatine transport

Disease: Cerebral Creatine Deficiency Syndrome 1