SLC6A1 blocking peptide

SLC6A1 Peptide

Cat. Num. AAA3005866

• Gene Names: SLC6A1; MAE; GAT1; GABATR; GABATHG
• Applications: Blocking
• Purity: Synthetic peptide SLC6A1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SLC6A1; SLC6A1 Peptide; Sodium- and chloride-dependent GABA transporter 1; GAT-1; Solute carrier family 6 member 1; GABATR; GABT1; GAT1; GABA T-1; GABA T1; GABAT1; SLC6A1 blocking peptide

• Specificity: This peptide can be used with studies using MBS3005865 SLC6A1 pAb.
• Purity/Purification: Synthetic peptide SLC6A1. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 599

• Applicable Applications for SLC6A1 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SLC6A1 blocking peptide

GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct. Members of the GABAA receptor family include GABAA Ralpha1-6, GABAA R beta1-3, GABAA Rgamma1-3, GABAA Rdelta, GABAA Repsilon, GABAA R?1 and GABAA R?2. The GABAB family is composed of GABAB R1alpha and GABAB R1beta. GABA transporters have also been identified and include GABA T-1, GABA T-2 and GABA T-3 (also designated GAT-1, -2, and -3). The GABA transporters function to terminate GABA action.

NCBI and Uniprot Product Information

• NCBI GI #: 188528618
• NCBI GeneID: 6529
• NCBI Accession #: NP_003033.3
• NCBI GenBank Nucleotide #: NP_003033.3
• UniProt Accession #: P30531
• NCBI Official Full Name: sodium- and chloride-dependent GABA transporter 1 isoform a
• NCBI Official Synonym Full Names: solute carrier family 6 member 1
• NCBI Official Symbol: SLC6A1
• NCBI Official Synonym Symbols: MAE; GAT1; GABATR; GABATHG
• NCBI Protein Information: sodium- and chloride-dependent GABA transporter 1
• UniProt Protein Name: Sodium- and chloride-dependent GABA transporter 1
• Protein Family: Sodium- and chloride-dependent GABA transporter
• UniProt Gene Name: SLC6A1
• UniProt Synonym Gene Names: GABATR; GABT1; GAT1; GAT-1
• UniProt Entry Name: SC6A1_HUMAN

NCBI Description

The protein encoded by this gene is a gamma-aminobutyric acid (GABA) transporter that localizes to the plasma membrane. The encoded protein removes GABA from the synaptic cleft, restoring it to presynaptic terminals. [provided by RefSeq, Jan 2017]

Uniprot Description

SLC6A1: Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals. Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A1 subfamily.

Protein type: Membrane protein, multi-pass; Transporter; Transporter, SLC family; Membrane protein, integral

Chromosomal Location of Human Ortholog: 3p25.3

Cellular Component: cell surface; membrane; integral to plasma membrane; axon; plasma membrane; integral to membrane

Molecular Function: gamma-aminobutyric acid:sodium symporter activity; neurotransmitter:sodium symporter activity

Biological Process: response to purine; response to toxin; neurotransmitter secretion; learning; response to cocaine; response to estradiol stimulus; response to sucrose stimulus; synaptic transmission; transport; response to lead ion; gamma-aminobutyric acid import; negative regulation of synaptic transmission, GABAergic; response to calcium ion; transmembrane transport; protein homooligomerization; positive regulation of gamma-aminobutyric acid secretion

Disease: Myoclonic-atonic Epilepsy