SLC22A4 blocking peptide

SLC22A4 Blocking Peptide

Cat. Num. AAA9628745

• Gene Names: SLC22A4; OCTN1
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: SLC22A4; SLC22A4 Blocking Peptide; Ergothioneine transporter; ET transporter; integral membrane transport protein; LSTP Like 2; MGC34546; MGC40524; Octn1; Organic cation transporter 1; Organic cation/carnitine transporter 1; RP23-354D12.1; S22A4_HUMAN; Slc22a4; Solute carrier family (organic cation transporter); member 4; solute carrier family 22 (organic cation/zwitterion transporter); Solute carrier family 22 member 4; SLC22A4 blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SLC22A4 blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SLC22A4 blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 24497490
• NCBI GeneID: 6583
• NCBI Accession #: NP_003050.2
• NCBI GenBank Nucleotide #: NM_003059.2
• UniProt Accession #: Q9H015; O14546
• Molecular Weight: 62,155 Da
• NCBI Official Full Name: solute carrier family 22 member 4
• NCBI Official Synonym Full Names: solute carrier family 22 (organic cation/zwitterion transporter), member 4
• NCBI Official Symbol: SLC22A4
• NCBI Official Synonym Symbols: OCTN1
• NCBI Protein Information: solute carrier family 22 member 4; ET transporter; ergothioneine transporter; integral membrane transport protein; organic cation/carnitine transporter 1; solute carrier family 22 (organic cation/ergothioneine transporter), member 4
• UniProt Protein Name: Solute carrier family 22 member 4
• Protein Family: Solute carrier family
• UniProt Gene Name: SLC22A4
• UniProt Synonym Gene Names: ETT; OCTN1; UT2H; ET transporter
• UniProt Entry Name: S22A4_HUMAN

NCBI Description

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent. [provided by RefSeq, Jul 2008]

Uniprot Description

SLC22A4: Sodium-ion dependent, low affinity carnitine transporter. Probably transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 1.78. A key substrate of this transporter seems to be ergothioneine (ET). Genetic variations in SLC22A4 are a cause of susceptibility to rheumatoid arthritis (RA). It is a systemic inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures. Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.

Protein type: Mitochondrial; Transporter; Transporter, SLC family; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q31.1

Cellular Component: mitochondrion; integral to plasma membrane; apical plasma membrane; plasma membrane

Molecular Function: protein binding; cation:cation antiporter activity; symporter activity; nucleotide binding; carnitine transporter activity; secondary active organic cation transmembrane transporter activity; quaternary ammonium group transmembrane transporter activity; ATP binding; PDZ domain binding

Biological Process: organic cation transport; triacylglycerol metabolic process; quaternary ammonium group transport; sodium ion transport; carnitine metabolic process; body fluid secretion; transmembrane transport; carnitine transport

Disease: Rheumatoid Arthritis