SLC16A2 blocking peptide

SLC16A2 Peptide

Cat. Num. AAA3005978

• Gene Names: SLC16A2; AHDS; MCT7; MCT8; XPCT; MCT 7; MCT 8; MRX22; DXS128; DXS128E
• Applications: Blocking
• Purity: Synthetic peptide SLC16A2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: SLC16A2; SLC16A2 Peptide; Monocarboxylate transporter 8; MCT 8; Monocarboxylate transporter 7; MCT 7; MCT7; Solute carrier family 16 member 2; X-linked PEST-containing transporter; MCT8; XPCT; SLC16A2 blocking peptide

• Specificity: This peptide can be used with studies using MBS3005977 SLC16A2 pAb.
• Purity/Purification: Synthetic peptide SLC16A2. (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 539

• Applicable Applications for SLC16A2 blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for SLC16A2 blocking peptide

Monocarboxylates, such as lactate and pyruvate, play an integral role in cellular metabolism. Lactic acid is produced in large quantities as a result of glycolysis, which provides the majority of ATP to cells under normal physiological conditions. However, accumulation of lactic acid leads to a decrease in intracellular pH and cessation of glycolysis. In order for glycolysis to continue at a high rate, lactic acid must be transported out of the cell. This transport process is carried out by a family of monocarboxylate transporters (MCTs), which function as proton symports and are stereoselective for L-lactate. The MCT family consists of at least eight members, MCT 1-8, which contain between 10-12 transmembrane-helical (TM) domains, with the amino and carboxy termini located in the cytoplasm. Defects in the gene encoding for MCT8, SLC16A2, can cause monocarboxylate transporter 8 deficiencey (MCT8 deficiency), a defect in cellular hormone transport causing a severe form of X-linked psychomotor retardation and abnormal thyroid levels.

NCBI and Uniprot Product Information

• NCBI GI #: 383087728
• NCBI GeneID: 6567
• NCBI Accession #: NP_006508.2
• NCBI GenBank Nucleotide #: NP_006508.2
• UniProt Accession #: P36021
• NCBI Official Full Name: monocarboxylate transporter 8
• NCBI Official Synonym Full Names: solute carrier family 16 member 2
• NCBI Official Symbol: SLC16A2
• NCBI Official Synonym Symbols: AHDS; MCT7; MCT8; XPCT; MCT 7; MCT 8; MRX22; DXS128; DXS128E
• NCBI Protein Information: monocarboxylate transporter 8
• UniProt Protein Name: Monocarboxylate transporter 8
• Protein Family: Monocarboxylate transporter
• UniProt Gene Name: SLC16A2
• UniProt Synonym Gene Names: MCT8; XPCT; MCT 8; MCT 7
• UniProt Entry Name: MOT8_HUMAN

NCBI Description

This gene encodes an integral membrane protein that functions as a transporter of thyroid hormone. The encoded protein facilitates the cellular importation of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). This gene is expressed in many tissues and likely plays an important role in the development of the central nervous system. Loss of function mutations in this gene are associated with psychomotor retardation in males while females exhibit no neurological defects and more moderate thyroid-deficient phenotypes. This gene is subject to X-chromosome inactivation. Mutations in this gene are the cause of Allan-Herndon-Dudley syndrome. [provided by RefSeq, Mar 2012]

Uniprot Description

SLC16A2: Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr. Defects in SLC16A2 are the cause of monocarboxylate transporter 8 deficiency (MCT8 deficiency); also known as Allan-Herndon-Dudley syndrome (AHDS). MCT8 deficiency consists of a severe form of X-linked psychomotor retardation combined with abnormal thyroid hormone (TH) levels. Thyroid hormone deficiency can be caused by defects of hormone synthesis and action, but it has also been linked to a defect in cellular hormone transport. Affected patients are males with abnormal relative concentrations of three circulating iodothyronines, as well as severe neurological abnormalities, including global developmental delay, central hypotonia, spastic quadriplegia, dystonic movements, rotary nystagmus, and impaired gaze and hearing. Heterozygous females had a milder thyroid phenotype and no neurological defects. Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter, SLC family; Transporter

Chromosomal Location of Human Ortholog: Xq13.2

Cellular Component: membrane; integral to plasma membrane; integral to membrane

Molecular Function: thyroid hormone transmembrane transporter activity; monocarboxylic acid transmembrane transporter activity; transporter activity; symporter activity

Biological Process: monocarboxylic acid transport; transport

Disease: Allan-herndon-dudley Syndrome