SIGLEC6 blocking peptide

SIGLEC6 Antibody (C-term) Blocking Peptide

• Gene Names: SIGLEC6; CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327
• Synonyms: SIGLEC6; SIGLEC6 Antibody (C-term) Blocking Peptide; Sialic acid-binding Ig-like lectin 6; Siglec-6; CD33 antigen-like 1; CDw327; Obesity-binding protein 1; OB-BP1; CD327; CD33L; CD33L1; OBBP1; SIGLEC6 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SIGLEC6. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 453

• Cellular Location: Isoform 1: Cell membrane; Single-pass type I membrane protein
• Tissue Location: Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SIGLEC6 blocking peptide

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

NCBI and Uniprot Product Information

• NCBI GI #: 193794821
• NCBI GeneID: 946
• NCBI Accession #: NP_001236
• NCBI GenBank Nucleotide #: NM_001245.6
• UniProt Accession #: O43699; O15388; O43700; A8MV71; B2RTS8; C9JBE5; F8WA78
• Molecular Weight: 44,348 Da
• NCBI Official Full Name: sialic acid-binding Ig-like lectin 6 isoform 1
• NCBI Official Synonym Full Names: sialic acid binding Ig like lectin 6
• NCBI Official Symbol: SIGLEC6
• NCBI Official Synonym Symbols: CD327; CD33L; OBBP1; CD33L1; CD33L2; CDW327
• NCBI Protein Information: sialic acid-binding Ig-like lectin 6
• UniProt Protein Name: Sialic acid-binding Ig-like lectin 6
• Protein Family: Sialic acid-binding Ig-like lectin
• UniProt Gene Name: SIGLEC6
• UniProt Synonym Gene Names: CD33L; CD33L1; OBBP1; Siglec-6; OB-BP1
• UniProt Entry Name: SIGL6_HUMAN

NCBI Description

This gene encodes a member of the SIGLEC (sialic acid binding immunoglobulin-like lectin) family of proteins. The encoded transmembrane receptor binds sialyl-TN glycans and leptin. Placental expression of the encoded protein is upregulated in preeclampsia. [provided by RefSeq, Jul 2016]

Uniprot Description

SIGLEC6: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, misc.; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane; membrane

Molecular Function: protein binding

Biological Process: cell-cell signaling