SHANK3 blocking peptide

SHANK3 Blocking Peptide

Gene Names

Shank3; Shank3b; AI841104; SHANK3c-3; SHANK3c-4

Applications

Immunodepletion, Immunocompetition

Synonyms

SHANK3; SHANK3 Blocking Peptide; Antigenic Blocking Peptide SH3 and multiple ankyrin repeat domains protein 3 Antibody; AI841104 antibody; DEL22q13.3 antibody; KIAA1650 antibody; Proline-rich synapse-associated protein 2 antibody; PSAP2 antibody; SH3 and multiple ankyrin repeat domains 3 antibody; SH3/ankyrin domain gene 3 antibody; SHAN3_HUMAN antibody; Shank postsynaptic density protein antibody; Shank3 antibody; Shank3b antibody; SPANK 2 antibody; SHANK3 blocking peptide

Ordering
Cat. Num. AAA5400653 For Research Use Only!

Sequence Length

1730

Applicable Applications for SHANK3 blocking peptide

Immunodepletion, Immunocompetition

Molecular Function

GFAP/Homer scaffold activity; identical protein binding; ionotropic glutamate receptor binding; protein C-terminus binding; scaffold protein binding; SH3 domain binding; zinc ion binding

Subcellular Location

Cell junction; Cell Membrane; Cell projection; Cytoplasm; Membrane; Postsynaptic Cell Membrane; Synapse

Preparation and Storage

Store at -20 degree C for long term storage.

Related Product Information for SHANK3 blocking peptide

Overview: Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.

Peptide Description: Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3.

Structure: Belongs to the SHANK family. Contains 6 ANK repeats. Contains 1 PDZ (DHR) domain. Contains 1 SAM (sterile alpha motif) domain. Contains 1 SH3 domain.

Expression: In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum

NCBI and Uniprot Product Information

NCBI GI #

71896543

NCBI GeneID

58234

NCBI Accession #

NP_067398.2

NCBI GenBank Nucleotide #

NM_021423.3

UniProt Accession #

Q4ACU6; Q69ZD8; Q9JJZ3; F8S0X0; F8S0X2; F8S0X3; F8S0X5; F8S0X6; S6BMD3; S6CCV8

Molecular Weight

88,196 Da

NCBI Official Full Name

SH3 and multiple ankyrin repeat domains protein 3

NCBI Official Synonym Full Names

SH3 and multiple ankyrin repeat domains 3

NCBI Official Symbol

Shank3

NCBI Official Synonym Symbols

Shank3b; AI841104; SHANK3c-3; SHANK3c-4

NCBI Protein Information

SH3 and multiple ankyrin repeat domains protein 3

UniProt Protein Name

SH3 and multiple ankyrin repeat domains protein 3

Protein Family

SH3 and multiple ankyrin repeat domains protein

UniProt Gene Name

Shank3

UniProt Synonym Gene Names

Kiaa1650; Prosap2; Shank3; ProSAP2

Uniprot Description

Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation.

Research Articles on SHANK3

1. Overexpression of SHANK3 enhanced ZO-1 expression, and knockdown of SHANK3 resulted in decreased expression of ZO-1. Regulation of ZO-1 expression by SHANK3 seems to be mediated through a PKCepsilon-dependent pathway. The expression level of SHANK3 affects ZO-1 expression and the barrier function in intestinal epithelial cells in mice.

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Product Notes

The SHANK3 shank3 (Catalog #AAA5400653) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's SHANK3 can be used in a range of immunoassay formats including, but not limited to, Immunodepletion, Immunocompetition. Researchers should empirically determine the suitability of the SHANK3 shank3 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SHANK3, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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SHANK3 blocking peptide