SH3BP4 blocking peptide

SH3BP4 Antibody(Center) Blocking peptide

• Gene Names: SH3BP4; TTP; BOG25
• Synonyms: SH3BP4; SH3BP4 Antibody(Center) Blocking peptide; SH3 domain-binding protein 4; EH-binding protein 10; Transferrin receptor-trafficking protein; BOG25; EHB10; TTP; SH3BP4 blocking peptide

• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 963

• Cellular Location: Membrane, clathrin-coated pit. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus Note: Specifically associated with transferrin receptor-containing clathrin-coated pits and clathrin-coated vesicles. May also localize to the nucleus
• Tissue Location: Expressed in all tissues tested with higher expression in pancreas. Expressed by retinal pigment epithelial cells (at protein level).
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SH3BP4 blocking peptide

May function in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. Alternatively, may acts as a negative regulator of the amino acid-induced TOR signaling by inhibiting the formation of active Rag GTPase complexes. Preferentially binds inactive Rag GTPase complexes and prevents their interaction with the mTORC1 complex inhibiting its relocalization to lysosomes and its activation. Thereby, may indirectly regulate cell growth, proliferation and autophagy.

NCBI and Uniprot Product Information

• NCBI GI #: 74753102
• NCBI GeneID: 23677
• UniProt Accession #: Q9P0V3; O95082; Q309A3; Q53QD0; Q53TD1
• Molecular Weight: 60,337 Da
• NCBI Official Full Name: SH3 domain-binding protein 4
• NCBI Official Synonym Full Names: SH3 domain binding protein 4
• NCBI Official Symbol: SH3BP4
• NCBI Official Synonym Symbols: TTP; BOG25
• NCBI Protein Information: SH3 domain-binding protein 4
• UniProt Protein Name: SH3 domain-binding protein 4
• Protein Family: SH3 domain-binding protein
• UniProt Gene Name: SH3BP4
• UniProt Synonym Gene Names: BOG25; EHB10; TTP
• UniProt Entry Name: SH3B4_HUMAN

NCBI Description

This gene encodes a protein with 3 Asn-Pro-Phe (NPF) motifs, an SH3 domain, a PXXP motif, a bipartite nuclear targeting signal, and a tyrosine phosphorylation site. This protein is involved in cargo-specific control of clathrin-mediated endocytosis, specifically controlling the internalization of a specific protein receptor. [provided by RefSeq, Jul 2008]

Uniprot Description

SH3BP4: Functions in transferrin receptor internalization at the plasma membrane through a cargo-specific control of clathrin- mediated endocytosis. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell cycle regulation; Vesicle

Chromosomal Location of Human Ortholog: 2q37.1-q37.2

Cellular Component: cytoplasm

Molecular Function: GDP-dissociation inhibitor activity; identical protein binding; protein binding; Ras GTPase binding

Biological Process: amino acid import; negative regulation of cell growth; negative regulation of cell proliferation; negative regulation of TOR signaling pathway; positive regulation of autophagy; regulation of catalytic activity