SENP5 blocking peptide

SENP5 Antibody (C-term) Blocking Peptide

• Synonyms: SENP5; SENP5 Antibody (C-term) Blocking Peptide; Sentrin-specific protease 5; Sentrin/SUMO-specific protease SENP5; SENP5 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human SENP5. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
• Sequence Length: 755

• Cellular Location: Nucleus, nucleolus
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SENP5 blocking peptide

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

NCBI and Uniprot Product Information

• NCBI GI #: 296452962
• NCBI GeneID: 205564
• UniProt Accession #: Q96HI0; Q96SA5; B4DY82
• Molecular Weight: 81,310 Da
• NCBI Official Full Name: Sentrin-specific protease 5
• NCBI Official Synonym Full Names: SUMO1/sentrin specific peptidase 5
• NCBI Official Symbol: SENP5
• NCBI Protein Information: sentrin-specific protease 5
• UniProt Protein Name: Sentrin-specific protease 5
• Protein Family: Sentrin-specific protease
• UniProt Gene Name: SENP5
• UniProt Entry Name: SENP5_HUMAN

NCBI Description

The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for numerous biologic processes. SUMO-specific proteases, such as SENP5, are responsible for the initial processing of SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also have isopeptidase activity for the removal of SUMO from high molecular mass SUMO conjugates (Di Bacco et al., 2006 [PubMed 16738315]).[supplied by OMIM, Jun 2009]

Uniprot Description

SENP5: Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division. Belongs to the peptidase C48 family.

Protein type: Nucleolus; Protease; EC 3.4.22.68

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: intracellular membrane-bound organelle; nucleolus; nucleoplasm; nucleus

Molecular Function: endopeptidase activity; protein binding; SUMO-specific protease activity

Biological Process: protein desumoylation; protein sumoylation