SEMA3A blocking peptide

SEMA3A Blocking Peptide

Cat. Num. AAA9627638

• Gene Names: SEMA3A; HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: SEMA3A; SEMA3A Blocking Peptide; Coll 1; Coll1; Collapsin 1; HH16; Hsema I; Hsema III; Sema domain immunoglobulin domain (Ig) short basic domain secreted (semaphorin) 3A; sema domain; immunoglobulin domain (Ig); short basic domain; secreted; (semaphorin) 3A; Sema III; SEMA1; SEMA1-PEN; SEMAD; SEMAIII; SEMAL; Semaphorin 3A precursor; Semaphorin III; semaphorin L; Semaphorin like growth cone guidance homolog of chick collapsin; Semaphorin-D; Semaphorin3A; SemD; SEMA3A blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for SEMA3A blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for SEMA3A blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 5174673
• NCBI GeneID: 10371
• NCBI Accession #: NP_006071.1
• NCBI GenBank Nucleotide #: NM_006080.2
• UniProt Accession #: Q14563
• Molecular Weight: 88,889 Da
• NCBI Official Full Name: semaphorin-3A
• NCBI Official Synonym Full Names: semaphorin 3A
• NCBI Official Symbol: SEMA3A
• NCBI Official Synonym Symbols: HH16; SemD; COLL1; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III
• NCBI Protein Information: semaphorin-3A
• UniProt Protein Name: Semaphorin-3A
• Protein Family: Semaphorin
• UniProt Gene Name: SEMA3A
• UniProt Synonym Gene Names: SEMAD; Sema III

NCBI Description

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq, Jul 2008]

Uniprot Description

Involved in the development of the olfactory system and in neuronal control of puberty. Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1.