Rps6ka1 blocking peptide

Rps6ka1 Blocking Peptide (C-term)

• Gene Names: Rps6ka1; Rsk; Rsk1; Rsk-1; p90S6K; p90rsk; p90Rsk1; p90-Rsk1; Mapkapk-1a; S6K-alpha-1
• Synonyms: Rps6ka1; Rps6ka1 Blocking Peptide (C-term); Rps6ka1 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 704-718 of HUMAN Rps6ka1
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 724

• Cellular Location: Nucleus. Cytoplasm
• Tissue Location: Intestine, thymus, and lung.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for Rps6ka1 blocking peptide

Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1. In fibroblast, is required for EGF-stimulated phosphorylation of CREB1, which results in the subsequent transcriptional activation of several immediate-early genes. In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP. Upon insulin- derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity. Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex. In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation. Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway. Mediates cell survival by phosphorylating the pro- apoptotic proteins BAD and DAPK1 and suppressing their pro- apoptotic function. Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4). Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity).

NCBI and Uniprot Product Information

• NCBI GI #: 125690
• NCBI GeneID: 20111
• UniProt Accession #: P18653
• Molecular Weight: 81,595 Da
• NCBI Official Full Name: Ribosomal protein S6 kinase alpha-1
• NCBI Official Synonym Full Names: ribosomal protein S6 kinase polypeptide 1
• NCBI Official Symbol: Rps6ka1
• NCBI Official Synonym Symbols: Rsk; Rsk1; Rsk-1; p90S6K; p90rsk; p90Rsk1; p90-Rsk1; Mapkapk-1a; S6K-alpha-1
• NCBI Protein Information: ribosomal protein S6 kinase alpha-1
• UniProt Protein Name: Ribosomal protein S6 kinase alpha-1
• Protein Family: Ribosomal protein S6 kinase
• UniProt Gene Name: Rps6ka1
• UniProt Synonym Gene Names: Mapkapk1a; Rsk1; S6K-alpha-1; p90-RSK 1; p90RSK1; p90S6K; MAPK-activated protein kinase 1a; MAPKAP kinase 1a; MAPKAPK-1a; RSK-1
• UniProt Entry Name: KS6A1_MOUSE

Uniprot Description

p90RSK: an AGC kinase of the RSK family. Phosphorylated and activated by Erk1 and -2 in response to many growth factors, polypeptide hormones and neurotransmitters. Several phosphorylation sites are important for its activation. Possesses two kinase domains connected by a regulator linker region. Phosphorylates a wide range of substrates including ribosomal protein S6. Prominently expressed in brain structures essential for cognitive function and learning.

Protein type: Kinase, protein; Translation; Protein kinase, Ser/Thr (non-receptor); Protein kinase, AGC; EC 2.7.11.1; AGC group; RSK family; RSK subfamily

Cellular Component: cytoplasm; nucleus; spindle

Molecular Function: caspase inhibitor activity; kinase activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; transcription factor binding

Biological Process: negative regulation of apoptosis; negative regulation of caspase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation