RGR blocking peptide

RGR Blocking Peptide

Cat. Num. AAA9623089

• Gene Names: RGR; RP44
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: RGR; RGR Blocking Peptide; hRGR; Ral GDS related protein; Retinal G protein coupled receptor; RGR-opsin; RP44; RPE retinal G protein coupled receptor; RGR blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for RGR blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RGR blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 61744454
• NCBI GeneID: 5995
• NCBI Accession #: NP_001012738.1
• NCBI GenBank Nucleotide #: NM_001012720.1
• UniProt Accession #: P47804; Q96FC5; A6NKK7
• Molecular Weight: 31,874 Da
• NCBI Official Full Name: RPE-retinal G protein-coupled receptor isoform 2
• NCBI Official Synonym Full Names: retinal G protein coupled receptor
• NCBI Official Symbol: RGR
• NCBI Official Synonym Symbols: RP44
• NCBI Protein Information: RPE-retinal G protein-coupled receptor; RGR-opsin; RPE retinal G-protein coupled receptor
• UniProt Protein Name: RPE-retinal G protein-coupled receptor
• Protein Family: RPE-retinal G protein-coupled receptor
• UniProt Gene Name: RGR
• UniProt Entry Name: RGR_HUMAN

Uniprot Description

RGR: Receptor for all-trans- and 11-cis-retinal. Binds preferentially to the former and may catalyze the isomerization of the chromophore by a retinochrome-like mechanism. Defects in RGR are the cause of retinitis pigmentosa type 44 (RP44). RP44 is a retinal dystrophy belonging to the group of pigmentary retinopathies. Retinitis pigmentosa is characterized by retinal pigment deposits visible on fundus examination and primary loss of rod photoreceptor cells followed by secondary loss of cone photoreceptors. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. Belongs to the G-protein coupled receptor 1 family. Opsin subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 10q23

Cellular Component: integral to plasma membrane

Molecular Function: G-protein coupled receptor activity; protein binding; chemokine receptor activity; photoreceptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; visual perception; phototransduction; chemotaxis; protein-chromophore linkage

Disease: Retinitis Pigmentosa 44