RFX4 blocking peptide

RFX4 Blocking Peptide (C-term)

• Gene Names: RFX4; NYD-SP10
• Synonyms: RFX4; RFX4 Blocking Peptide (C-term); Transcription factor RFX4; Regulatory factor X 4; Testis development protein NYD-SP10; RFX4 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 684-700 of HUMAN RFX4
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 735

• Cellular Location: Nucleus
• Tissue Location: Isoform 4 is testis-specific. Isoform 1 is expressed in brain and gliomas. Isoform 2 and isoform 3 are testis-specific (at protein level). Isoform 1 is expressed in brain (at protein level). Isoform 3 is expressed at a higher level in adult testes and ejaculated spematozoa than in fetal testes
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RFX4 blocking peptide

May activate transcription by interacting directly with the X-box.

NCBI and Uniprot Product Information

• NCBI GI #: 332278145
• NCBI GeneID: 5992
• UniProt Accession #: Q33E94; Q33DW6; Q33DW7; Q33E95; Q6YM53; Q8MHQ1; Q8NC78; Q8NDF9; Q8SNA1; Q96S80; A8K5Y0; B2RDW4
• Molecular Weight: 64,181 Da
• NCBI Official Full Name: Transcription factor RFX4
• NCBI Official Synonym Full Names: regulatory factor X4
• NCBI Official Symbol: RFX4
• NCBI Official Synonym Symbols: NYD-SP10
• NCBI Protein Information: transcription factor RFX4
• UniProt Protein Name: Transcription factor RFX4
• Protein Family: Transcription factor
• UniProt Gene Name: RFX4
• UniProt Entry Name: RFX4_HUMAN

NCBI Description

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]

Uniprot Description

RFX4: May activate transcription by interacting directly with the X-box. Belongs to the RFX family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 12q24

Cellular Component: nucleus

Molecular Function: protein binding

Biological Process: cilium biogenesis; negative regulation of smoothened signaling pathway in ventral spinal cord patterning; positive regulation of transcription from RNA polymerase II promoter