RASIP1 blocking peptide

RASIP1 Antibody (Center) Blocking Peptide

• Gene Names: RASIP1; RAIN
• Synonyms: RASIP1; RASIP1 Antibody (Center) Blocking Peptide; Ras-interacting protein 1; Rain; RASIP1 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the Center region of human RASIP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 963

• Cellular Location: Cytoplasm, perinuclear region. Golgi apparatus, Golgi stack. Note: Associated with perinuclear vesicles. Is recruited to Golgi stacks by activated HRAS
• Tissue Location: Highly expressed in heart. Detected at lower levels in placenta and pancreas.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for RASIP1 blocking peptide

Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells (By similarity). May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS- mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

NCBI and Uniprot Product Information

• NCBI GI #: 74736209
• NCBI GeneID: 54922
• UniProt Accession #: Q5U651; Q6U676
• Molecular Weight: 103,457 Da
• NCBI Official Full Name: Ras-interacting protein 1
• NCBI Official Synonym Full Names: Ras interacting protein 1
• NCBI Official Symbol: RASIP1
• NCBI Official Synonym Symbols: RAIN
• NCBI Protein Information: ras-interacting protein 1
• UniProt Protein Name: Ras-interacting protein 1
• Protein Family: Ras-interacting protein
• UniProt Gene Name: RASIP1
• UniProt Synonym Gene Names: Rain
• UniProt Entry Name: RAIN_HUMAN

Uniprot Description

RASIP1: Required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis. Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis. Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells. May act as effector for Golgi-bound HRAS and other Ras-like proteins. May promote HRAS- mediated transformation. Negative regulator of amino acid starvation-induced autophagy.

Protein type: Cell cycle regulation; GAPs; GAPs, Ras

Chromosomal Location of Human Ortholog: 19q13.33

Biological Process: angiogenesis; branching morphogenesis of a tube; negative regulation of autophagy; regulation of GTPase activity; vasculogenesis