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RAB7B blocking peptide

RAB7B Blocking Peptide (C-term)

Gene Names
RAB7B; RAB7
Synonyms
RAB7B; RAB7B Blocking Peptide (C-term); Ras-related protein Rab-7b; RAB7B blocking peptide
Ordering
Specificity
The synthetic peptide sequence is selected from aa 183-197 of HUMAN RAB7B
Form/Format
Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
Sequence Length
199
Cellular Location
Late endosome. Lysosome. Golgi apparatus, trans-Golgi network. Golgi apparatus. Cytoplasmic vesicle, phagosome. Cytoplasmic vesicle, phagosome membrane; Lipid-anchor; Cytoplasmic side Note: Recruited to phagosomes containing S.aureus or M.tuberculosis
Tissue Location
Expressed in heart, placenta, lung, skeletal muscle and peripheral blood leukocyte
Preparation and Storage
Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.
Related Product Information for RAB7B blocking peptide
Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
22,511 Da
NCBI Official Full Name
ras-related protein Rab-7b isoform a
NCBI Official Synonym Full Names
RAB7B, member RAS oncogene family
NCBI Official Symbol
RAB7B
NCBI Official Synonym Symbols
RAB7
NCBI Protein Information
ras-related protein Rab-7b
UniProt Protein Name
Ras-related protein Rab-7b
Protein Family
UniProt Gene Name
RAB7B
UniProt Entry Name
RAB7B_HUMAN

Uniprot Description

RAB7B: Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway. Belongs to the small GTPase superfamily. Rab family.

Protein type: G protein, monomeric; G protein, monomeric, Rab; G protein

Chromosomal Location of Human Ortholog: 1q32

Cellular Component: Golgi apparatus; late endosome; lysosome; phagocytic vesicle; trans-Golgi network

Biological Process: activation of NF-kappaB transcription factor; negative regulation of toll-like receptor 4 signaling pathway; negative regulation of toll-like receptor 9 signaling pathway; positive regulation of interleukin-6 production; positive regulation of megakaryocyte differentiation

Research Articles on RAB7B

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Product Notes

The RAB7B rab7b (Catalog #AAA9228727) is a Blocking Peptide and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RAB7B, Blocking Peptide" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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