PTGES2 blocking peptide

PTGES2 Blocking Peptide (Center)

• Gene Names: PTGES2; GBF1; GBF-1; PGES2; C9orf15; mPGES-2
• Synonyms: PTGES2; PTGES2 Blocking Peptide (Center); Prostaglandin E synthase 2; Membrane-associated prostaglandin E synthase-2; mPGE synthase-2; Microsomal prostaglandin E synthase 2; mPGES-2; Prostaglandin-H(2) E-isomerase; Prostaglandin E synthase 2 truncated form; C9orf15; PGES2; PTGES2 blocking peptide

• Specificity: The synthetic peptide sequence is selected from aa 133-146 of HUMAN PTGES2
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 377

• Cellular Location: Golgi apparatus membrane; Single-pass membrane protein
• Tissue Location: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes. Also expressed in the lymph nodes, skeletal muscle, kidney and trachea, but not in the thymus or lung. Overexpressed in colorectal cancer
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PTGES2 blocking peptide

Isomerase that catalyzes the conversion of PGH2 into the more stable prostaglandin E2 (PGE2).

NCBI and Uniprot Product Information

• NCBI GI #: 73921741
• NCBI GeneID: 80142
• UniProt Accession #: Q9H7Z7; Q53EW9; Q5SYV6; Q96GI0; Q96GL2
• Molecular Weight: 41,943 Da
• NCBI Official Full Name: Prostaglandin E synthase 2
• NCBI Official Synonym Full Names: prostaglandin E synthase 2
• NCBI Official Symbol: PTGES2
• NCBI Official Synonym Symbols: GBF1; GBF-1; PGES2; C9orf15; mPGES-2
• NCBI Protein Information: prostaglandin E synthase 2
• UniProt Protein Name: Prostaglandin E synthase 2
• Protein Family: Prostaglandin E synthase
• UniProt Gene Name: PTGES2
• UniProt Synonym Gene Names: C9orf15; PGES2; mPGES-2
• UniProt Entry Name: PGES2_HUMAN

NCBI Description

The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene. [provided by RefSeq, Jun 2009]

Uniprot Description

PTGES2: Isomerase that catalyzes the conversion of unstable intermediate of prostaglandin E2 H2 (PGH2) into the more stable prostaglandin E2 (PGE2) form. May also have transactivation activity toward IFN-gamma (IFNG), possibly via an interaction with CEBPB; however, the relevance of transcription activation activity remains unclear. Belongs to the GST superfamily.

Protein type: Lipid Metabolism - arachidonic acid; Isomerase; EC 5.3.99.3; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q34.11

Cellular Component: mitochondrion

Molecular Function: glutathione binding; heme binding; lyase activity; protein binding