PQLC2 blocking peptide

PQLC2 Antibody (C-term) Blocking Peptide

• Synonyms: PQLC2; PQLC2 Antibody (C-term) Blocking Peptide; Lysosomal amino acid transporter 1 homolog; PQ-loop repeat-containing protein 2; PQLC2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of PQLC2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 291

• Cellular Location: Lysosome membrane; Multi-pass membrane protein
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PQLC2 blocking peptide

Amino acid transporter that specifically mediates the pH-dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes.

NCBI and Uniprot Product Information

• NCBI GI #: 74749590
• NCBI GeneID: 54896
• UniProt Accession #: Q6ZP29; Q6ZMJ3; Q6ZP27; Q9NXC7; B3KWQ5
• Molecular Weight: 24,848 Da
• NCBI Official Full Name: Lysosomal amino acid transporter 1 homolog
• NCBI Official Synonym Full Names: PQ loop repeat containing 2
• NCBI Official Symbol: PQLC2
• NCBI Protein Information: lysosomal amino acid transporter 1 homolog
• UniProt Protein Name: Lysosomal amino acid transporter 1 homolog
• Protein Family: Lysosomal amino acid transporter
• UniProt Gene Name: PQLC2
• UniProt Entry Name: LAAT1_HUMAN

Uniprot Description

PQLC2: Lysosomal lysine/arginine transporter that specifically mediates the export of lysine and arginine from lysosomes. Belongs to the laat-1 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: intracellular membrane-bound organelle; lysosomal membrane

Molecular Function: arginine transmembrane transporter activity; basic amino acid transmembrane transporter activity; L-lysine transmembrane transporter activity

Biological Process: arginine transport; lysine transport