PDE4C blocking peptide

PDE4C Blocking Peptide

Cat. Num. AAA9624045

• Gene Names: PDE4C; DPDE1
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: PDE4C; PDE4C Blocking Peptide; 5''-cyclic phosphodiesterase 4C; cAMP specific 3' 5' cyclic phosphodiesterase 4C; cAMP-specific 3''; DPDE 1; DPDE1; MGC126222; PDE 21; PDE 4C; PDE21; Pde4c; PDE4C_HUMAN; Phosphodiesterase 4C; Phosphodiesterase 4C cAMP specific; cAMP specific (phosphodiesterase E1 dunce homolog; Drosophila); Phosphodiesterase E1 dunce homolog; Phosphodiesterase E1 dunce homolog Drosophila; Phosphodiesterase type 4C; PDE4C blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for PDE4C blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for PDE4C blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 115529445
• NCBI GeneID: 5143
• NCBI Accession #: NP_000914.2
• NCBI GenBank Nucleotide #: NM_000923.5
• UniProt Accession #: Q08493; Q9UN44; Q9UN45; Q9UN46; Q9UPJ6; B3KTC4
• Molecular Weight: 79,902 Da
• NCBI Official Full Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C isoform PDE4C1
• NCBI Official Synonym Full Names: phosphodiesterase 4C, cAMP-specific
• NCBI Official Symbol: PDE4C
• NCBI Official Synonym Symbols: DPDE1
• NCBI Protein Information: cAMP-specific 3',5'-cyclic phosphodiesterase 4C; PDE21; phosphodiesterase E1 dunce homolog; phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila)
• UniProt Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4C
• Protein Family: cAMP-specific 3',5'-cyclic phosphodiesterase
• UniProt Gene Name: PDE4C
• UniProt Synonym Gene Names: DPDE1
• UniProt Entry Name: PDE4C_HUMAN

NCBI Description

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

Uniprot Description

PDE4C: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 7 isoforms of the human protein are produced by alternative splicing.

Protein type: Phosphodiesterase; Nucleotide Metabolism - purine; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 19p13.11

Cellular Component: extracellular space; cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; metal ion binding

Biological Process: cAMP catabolic process; signal transduction