PDE4B/C/D blocking peptide

PDE4B/C/D (H47) Peptide

Cat. Num. AAA3001321

• Gene Names: PDE4D; DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
• Applications: Blocking
• Purity: Synthetic peptide PDE4B/C/D (H47). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Synonyms: PDE4B/C/D; PDE4B/C/D (H47) Peptide; cAMP-specific 3'; 5'-cyclic phosphodiesterase 4B; DPDE4; PDE32; PDE4B; 5'-cyclic phosphodiesterase 4D; DPDE3; PDE43; 5'-cyclic phosphodiesterase 4C; DPDE1; PDE21; PDE4C; PDE4B/C/D blocking peptide

• Specificity: This peptide can be used with studies using MBS3001320 PDE4B/C/D (H47) pAb.
• Purity/Purification: Synthetic peptide PDE4B/C/D (H47). (Note: the amino acid sequence is proprietary).; The purity is >98%.
• Form/Format: 1 mg/ml in DI water.
• Sequence Length: 518

• Applicable Applications for PDE4B/C/D blocking peptide: Blocking
• Preparation and Storage: Store at 4 degree C short term.; Aliquot and store at -20 degree C long term.; Avoid freeze-thaw cycles.

Related Product Information for PDE4B/C/D blocking peptide

Phosphodiesterases (PDE) hydrolyze cAMP to 5AMP and thus play a critical role in the regulation of intracellular cAMP. Division of the PDE superfamily by sequence homology and enzymatic properties yields 11 PDE families. A unique upstream conserved region (UCR) characterizes the PDE4 family. Four separate genes (A-D) encode the PDE4 enzymes, and alternative splicing generates short or long isoforms of each gene. Long PDE4 isoforms contain both UCR1 and UCR2 while short PDE4 isoforms possess only UCR2. Both UCR domains are necessary for dimerization of PDE4 isoforms. The human PDE4D gene maps to chromosome 5q12. The splice variants include isoforms PDE4D1-6.

NCBI and Uniprot Product Information

• NCBI GI #: 23274169
• NCBI GeneID: 5144
• UniProt Accession #: Q08499; Q07343; Q08493
• NCBI Official Full Name: PDE4D protein
• NCBI Official Synonym Full Names: phosphodiesterase 4D
• NCBI Official Symbol: PDE4D
• NCBI Official Synonym Symbols: DPDE3; PDE43; STRK1; ACRDYS2; HSPDE4D; PDE4DN2
• NCBI Protein Information: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
• UniProt Protein Name: cAMP-specific 3',5'-cyclic phosphodiesterase 4D
• UniProt Gene Name: PDE4D
• UniProt Synonym Gene Names: DPDE3
• UniProt Entry Name: PDE4D_HUMAN

NCBI Description

This gene encodes one of four mammalian counterparts to the fruit fly 'dunce' gene. The encoded protein has 3',5'-cyclic-AMP phosphodiesterase activity and degrades cAMP, which acts as a signal transduction molecule in multiple cell types. This gene uses different promoters to generate multiple alternatively spliced transcript variants that encode functional proteins.[provided by RefSeq, Sep 2009]

Uniprot Description

PDE4D: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1). Isoform 5, isoform N3 and isoform 12 bind GNB2L1 via their unique N-terminus. Binds ARRB2. Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle. Inhibited by rolipram. Activated by phosphatidic acid. Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily. 12 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Phosphodiesterase; EC 3.1.4.53

Chromosomal Location of Human Ortholog: 5q12

Cellular Component: Golgi apparatus; centrosome; membrane; myofibril; apical plasma membrane; voltage-gated calcium channel complex; cytosol

Molecular Function: 3',5'-cyclic-AMP phosphodiesterase activity; protein binding; enzyme binding; metal ion binding; ubiquitin protein ligase binding; beta-2 adrenergic receptor binding; drug binding; cAMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity; SH3 domain binding; ATPase binding

Biological Process: neutrophil chemotaxis; negative regulation of heart contraction; regulation of heart rate; multicellular organism growth; positive regulation of smooth muscle cell proliferation; cAMP catabolic process; negative regulation of peptidyl-serine phosphorylation; positive regulation of smooth muscle cell migration; T cell receptor signaling pathway; memory; positive regulation of interferon-gamma production; cAMP-mediated signaling; smooth muscle contraction; cellular protein complex assembly; positive regulation of interleukin-2 production; regulation of receptor activity; regulation of G-protein coupled receptor protein signaling pathway; positive regulation of interleukin-5 production; lung development; aging